Related Experiment Video
Updated: Jan 23, 2026

Method for Obtaining Primary Ovarian Cancer Cells From Solid Specimens
Published on: February 4, 2014
Primary Ovarian Insufficiency: Molecular Mechanisms and the Role of MicroRNAs
Fateme Arjmand1, Jamileh Sadat Mirsanei1,2, Rana Mehdizadeh3
1Reproductive Sciences and Technology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Abstract:
Primary ovarian insufficiency (POI) is a multifactorial disorder marked by ovarian function cessation before age 40, leading to infertility and systemic complications, including osteoporosis, cardiovascular disease, and neurocognitive impairment. It results from accelerated ovarian reserve depletion, impaired folliculogenesis, and hormonal dysregulation. The majority of cases are idiopathic, with known causes including genetic mutations, autoimmune disorders, infections, and iatrogenic factors. Recent RNA sequencing advances highlight microRNAs (miRNAs) as critical regulators of ovarian processes. Dysregulated miRNAs drive granulosa cell apoptosis, oxidative stress, and follicular atresia, with distinct profiles offering potential as biomarkers for early diagnosis and therapeutic targets. This review synthesizes miRNA-mediated mechanisms in POI, integrating their roles in apoptosis, DNA repair, and folliculogenesis, and evaluates miRNA-based diagnostics and therapies, including exosome-mediated delivery, to improve reproductive and clinical outcomes.
More Related Videos
Related Concept Videos
MicroRNAs
MicroRNAs
Insufficient Sleep and Sleep Deprivation
Sleep deprivation is a more severe form of sleep loss...
Reaction Mechanisms
For instance, the decomposition of ozone appears to follow a mechanism with two steps:
Molecular Models
Ovarian Cycle

