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Related Experiment Video

Updated: Jan 23, 2026

Microfluidic-based Synthesis of Covalent Organic Frameworks COFs: A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface

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Published on: July 10, 2017

Leveraging SiO₂-Infused COFs for PhotoPyro.

Hyeonji Rha¹, Nem Singh¹, Amit Sharma²

¹Department of Chemistry, Korea University, Seoul, South Korea.

Advanced Healthcare Materials

|January 22, 2026

Summary

This study introduces a novel SiO2@COF nanoplatform for phototherapy. This metal-free material enhances catalytic efficiency and enables precise biological control for advanced precision therapies.

Keywords:

NADH oxidation covalent organic frameworks photodynamic therapy: photoredox Catalysts pyroptosis

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Last Updated: Jan 23, 2026

Microfluidic-based Synthesis of Covalent Organic Frameworks COFs: A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface

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Area of Science:

Materials Science
Nanotechnology
Biomedical Engineering

Background:

Covalent organic frameworks (COFs) show therapeutic potential in phototheranostics.
Clinical translation is hindered by COF instability and poor performance in physiological conditions.

Purpose of the Study:

To develop a stable and high-performance COF-based nanoplatform for phototherapy.
To overcome the limitations of COFs in physiological environments.

Main Methods:

Post-synthetic modification (PSM) strategy to coat SiO2 nanoparticles with ultrathin COF layers.
Utilized Schiff-base condensation of TAPP and PDCA for COF layer formation.
Created a core-shell SiO2@COF architecture.

Main Results:

Enhanced photocatalytic NADH oxidation with significantly increased turnover frequency (TOF) under both normoxia and hypoxia.
Demonstrated robust, oxygen-independent catalytic efficiency.
Achieved efficient reactive oxygen species (ROS) generation and photon-controlled pyroptosis activation via the caspase-3/GSDME pathway.

Conclusions:

The SiO2@COF nanoplatform offers enhanced catalytic activity and stability.
This metal-free system provides precise biological control for phototherapy.
Represents a promising advancement for next-generation precision phototherapies.