Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Conservation Biology?01:57

What is Conservation Biology?

24.0K
Conservation biology is a scientific field that focuses on the preservation of biodiversity in order to protect ecosystems while meeting the needs of the human population. Humans require properly functioning ecosystems to maintain our supply of natural resources, including food, medicines, and building materials.
24.0K
Conservation of Small Populations02:04

Conservation of Small Populations

16.7K
Small population sizes put a species at extreme risk of extinction due to a lack of variation, and a consequent decrease in adaptability. This weakens the chances of survival under pressures such as climate change, competition from other species, or new diseases. Large populations are more likely to survive pressures such as these, as such populations are more likely to harbor individuals that have genetic variants that are adaptive under new stresses. Small populations are much less...
16.7K
Conserved Binding Sites01:49

Conserved Binding Sites

5.0K
Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
5.0K
Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

14.1K
Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
14.1K
Conservative Forces01:03

Conservative Forces

949
Conservative forces are an essential concept in the field of mechanical engineering. Understanding the properties and characteristics of these forces is crucial to the design and analysis of mechanical systems.
Conservative forces are forces that are dependent only on the initial and final positions of an object and that are independent of the path that the object takes between these positions. These forces conserve energy, which means that the work done by the force is independent of the path...
949
Conservative Forces01:14

Conservative Forces

14.0K
According to the law of conservation of energy, any transition between kinetic and potential energy conserves the total energy of the system. Hence, the work done by a conservative force is completely reversible. It is path independent, which means that we can start and stop at any two points in the transition, and the total energy of the system (kinetic plus potential energy at these points) will remain conserved. This is characteristic of a conservative force. Some important examples of...
14.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intrinsic Chemical Consequences of Interface Failure in Composite Insulators Under Electrical Stress: PD-Induced Degradation of Epoxy/Anhydride Matrix and the Role of Humidity.

Polymers·2026
Same author

Black Hole Quencher-Enhanced Plasmonic Photothermal Conversion.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Mitochondrial proteases maintain cellular protein homeostasis and tissue integrity.

Cell & bioscience·2026
Same author

Quencher-Enhanced Raman Scattering Probes With Large Scattering Cross-Section for NIR-II Surgical Navigation and Postsurgical Site Infection Management.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Rational design, antimicrobial mechanisms of non-perfectly amphipathic peptides with α-helical propensity.

Journal of structural biology·2026
Same author

Self-Assembling Enveloped Virus-Mimicking Particle for Extrahepatic Targeting mRNA Delivery.

ACS nano·2026

Related Experiment Video

Updated: Jan 23, 2026

Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery
11:05

Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery

Published on: September 19, 2014

12.7K

An Integrated NIR-II Fluorescence-Free Reporter for Multimodal Imaging-Guided Breast-Conserving Surgery.

Xinwei Wang1, Kexin Shi1, Ye Wang1

  • 1Department of Immunology, School of Basic Medicine, Jiamusi University, Jiamusi 154007, China.

Nano Letters
|January 22, 2026
PubMed
Summary

This study introduces a novel fluorescence-free reporter for enhanced breast cancer surgery. The developed trimodal nanoprobe (RPM nanoparticles) precisely delineates tumor margins, ensuring complete tumor resection and improving surgical outcomes.

Keywords:
Breast-conserving surgeryFluorescence-free reporterMultimodal imagingSecond near-infraredTumor margin

More Related Videos

Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial
03:07

Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial

Published on: August 19, 2025

853
A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery
09:41

A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery

Published on: May 20, 2016

12.7K

Related Experiment Videos

Last Updated: Jan 23, 2026

Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery
11:05

Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery

Published on: September 19, 2014

12.7K
Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial
03:07

Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial

Published on: August 19, 2025

853
A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery
09:41

A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery

Published on: May 20, 2016

12.7K

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Medical Imaging

Background:

  • Precise tumor margin delineation is critical for successful breast-conserving surgery.
  • Current methods face challenges in accurately identifying tumor boundaries.
  • Advanced imaging techniques are needed to improve surgical accuracy and patient outcomes.

Purpose of the Study:

  • To develop a novel fluorescence-free trimodal nanoprobe for enhanced breast tumor margin delineation.
  • To integrate magnetic resonance imaging (MRI), photoacoustic imaging (PAI), and Raman scattering imaging.
  • To improve the accuracy and completeness of tumor resection in breast cancer surgery.

Main Methods:

  • Development of nickel-containing NiS8 nanoparticles for fluorescence-free imaging.
  • Integration into RPM nanoparticles for trimodal imaging (MRI-PAI-Raman).
  • Preoperative MRI for tumor localization, intraoperative PAI/Raman for margin delineation, and postoperative Raman for validation.

Main Results:

  • NiS8 nanoparticles exhibit intense photon-resonant absorption and are nonemissive, enabling fluorescence-free imaging.
  • RPM nanoparticles demonstrated improved Raman/PAI properties and signal correlation.
  • Successful preoperative tumor identification, intraoperative margin delineation, and postoperative validation of complete resection.

Conclusions:

  • The developed fluorescence-free trimodal nanoprobes (RPM nanoparticles) offer a promising solution for precise breast tumor margin delineation.
  • This approach enhances surgical planning and execution, leading to improved tumor resection.
  • The trimodal imaging strategy facilitates accurate identification and validation of tumor-free margins, ultimately verifying complete tumor removal.