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A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging
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Quencher-Enhanced Raman Scattering Probes With Large Scattering Cross-Section for NIR-II Surgical Navigation and

Kexin Shi1,2,3, Xinwei Wang1, Ye Wang1

  • 1Department of Immunology, School of Basic Medicine, Jiamusi University, Jiamusi, China.

Small (Weinheim an Der Bergstrasse, Germany)
|June 2, 2026
PubMed
Summary
This summary is machine-generated.

Researchers developed novel nonfluorescent diammonium molecular building blocks (MBBs) for enhanced Raman scattering (QERS) probes. These probes enable precise tumor imaging and treatment, offering a new strategy for developing advanced Raman imaging agents.

Keywords:
plasmon‐free raman probespostsurgical hyperthermiaquencher building blocksraman‐guided surgerysecond near‐infrared

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Area of Science:

  • Biomedical Engineering
  • Chemical Engineering
  • Materials Science

Background:

  • Aggregation-induced emission (AIE) probes have advanced fluorescence imaging.
  • Plasmon-free Raman imaging probes require unique Raman-active molecular building blocks (MBBs) to enhance scattering.
  • Current Raman probes face limitations in scattering efficiency and fluorescence background.

Purpose of the Study:

  • To introduce a new concept of quencher-enhanced Raman scattering (QERS) using nonfluorescent diammonium MBBs.
  • To develop bright, plasmon-free Raman probes in the second near-infrared window.
  • To demonstrate the application of QERS probes in Raman-guided surgery and photothermal therapy.

Main Methods:

  • Synthesized large π-conjugated diammonium MBBs with high photon absorption and ultra-low fluorescence quantum yield.
  • Fabricated QERS probes via nanoprecipitation.
  • Evaluated probe performance in terms of Raman cross-section, photostability, and photothermal conversion efficiency.
  • Tested QERS probes in vivo for Raman-guided tumor surgery and hyperthermia ablation of bacteria in mice.

Main Results:

  • QERS probes exhibited a giant Raman cross-section (1.27 × 10-19 cm2) and remarkable photostability.
  • Achieved high-precision Raman-guided surgical removal of tumors in living mice.
  • Demonstrated high photothermal conversion efficiency (60.5%) for hyperthermia ablation of drug-resistant bacteria.
  • Successfully suppressed fluorescence backgrounds, enhancing imaging clarity.

Conclusions:

  • Quencher-enhanced Raman scattering (QERS) provides a robust strategy for developing bright, plasmon-free Raman probes.
  • QERS probes are effective for in vivo tumor imaging and surgical guidance.
  • QERS probes offer potential for photothermal therapy against drug-resistant infections.