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Updated: Jan 23, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Silver catalyzed cascade cyclization of 2-(allyloxy)arylaldehydes: synthesis of chroman-4-one derivatives
Jing Zhao1, Wenbin Guo1, Mei Fang1
1School of Life Science, Jiangxi Science and Technology Normal University, China. wlping92@163.com.
Abstract:
Herein, a novel cascade cyclization for the synthesis of oxyalkylated and 1,5-dicarbonylated chroman-4-ones from 2-(allyloxy)arylaldehydes is described. The transformation proceeded in the presence of a silver salt to generate a series of anticipated chroman-4-one derivatives in moderate to good yields, and the alcohols or ketones in this reaction were employed as both reaction media and oxyalkyl or carbonyl sources, exhibiting an atom-economical approach for the preparation of chroman-4-one skeletons.
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