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MMP9 Genetic Variants in Schizophrenia Spectrum Disorders and Its Relation with Cognitive Dysfunction and Suicide
Neha Keshri1, Hanumanthappa Nandeesha1, Vikas Menon2
1Dept. of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
Indian Journal of Psychological Medicine
|January 22, 2026
Summary
Matrix metalloproteinase-9 (MMP9) genetic variants are linked to schizophrenia spectrum disorders. However, these MMP9 variants did not correlate with cognitive deficits or suicide attempts in patients.
Area of Science:
- Neuroscience
- Genetics
- Psychiatry
Background:
- Schizophrenia spectrum disorders are complex psychiatric conditions with a significant genetic component.
- Matrix metalloproteinase-9 (MMP9) is implicated in various neurological processes, making it a candidate gene for schizophrenia.
Purpose of the Study:
- To investigate the association between specific MMP9 genetic variants (rs20544 and rs17576) and plasma MMP9 levels in patients with schizophrenia spectrum disorders.
- To explore the relationship between these MMP9 genetic factors, cognitive function, and suicide attempts in the studied population.
Main Methods:
- Genotyping of MMP9 variants rs20544 and rs17576 in 216 schizophrenia patients and 216 controls using TaqMan assay.
- Cognitive status assessed via Addenbrooke's Cognitive Examination III (ACE-III).
- Suicidal ideation evaluated using Columbia suicide severity rating (CSSR) scores; genetic data analyzed with chi-squared test, plasma MMP9 compared using Kruskal-Wallis test.
Main Results:
- The rs17576 variant (GG genotype, G allele) was more frequent in schizophrenia patients, while rs20544 (CC genotype, C allele) was less frequent.
- Higher plasma MMP9 levels were observed in TT and CT genotypes of rs20544 within the schizophrenia group.
- No significant association was found between MMP9 variants and cognitive impairment or suicide attempt severity.
Conclusions:
- Specific MMP9 genetic variants are associated with schizophrenia spectrum disorders.
- MMP9 genetic variations do not appear to be linked to cognitive impairment or suicide attempts in this patient cohort.
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