Related Experiment Video
Updated: Jan 23, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
Published on: April 9, 2014
Multidrug-Resistant Serratia marcescens Cavitary Pneumonia in an HIV Patient: A Case Report
Laxman Wagle1, Prachi Bhanvadia1, Sishir Poudel2
1Internal Medicine, Ascension Saint Agnes Hospital, Baltimore, USA.
None:
Serratia marcescens is an opportunistic gram-negative bacillus with both intrinsic and acquired resistance mechanisms, making it a challenging pathogen in immunocompromised individuals. We report a fatal case of cavitary pneumonia caused by multidrug-resistant S. marcescens in a 42-year-old HIV-positive man with chronic comorbidities, who presented with acute hypoxic respiratory failure and septic shock. Imaging revealed a large cavitary lesion in the right upper lobe, and cultures from blood, urine, and respiratory secretions confirmed S. marcescens with broad-spectrum antibiotic resistance. Despite aggressive medical management, including broad-spectrum antimicrobials, vasopressor support, bronchoscopy, and renal replacement therapy, the patient's condition deteriorated, resulting in death. This case underscores the rare but severe pulmonary manifestation of S. marcescens in immunocompromised hosts, emphasizing the importance of early recognition, infection control, and targeted antimicrobial therapy in managing such high-risk infections.
More Related Videos
19:57An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings
Published on: March 30, 2014
13:58Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays
Published on: September 26, 2011
Related Concept Videos
Data Reporting and Recording
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Pneumonia II: Pathophysiology
Pneumonia IV: Management
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Resistivity
Resistance