Related Experiment Video
Updated: Jan 23, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
Published on: July 16, 2017
Timing structures in live comedy: A matched-sequence approach to mapping performance dynamics
Vanessa C Pope1, Rebecca Stewart2, Elaine Chew1
1Department of Engineering and School of Biomedical Engineering & Imaging Sciences, King's College London, London WC2R 2LS, United Kingdom.
None:
Live performance is a ubiquitous cultural and social behavior that has not yet benefited from systematic scientific study. We present a computational methodology that visualizes and describes timing structures in live performance, showcasing their engineering. This novel analysis framework, Topology Analysis of Matching Sequences (TAMS), automatically detects matching sequences and maps their timing. Locating material that is repeated across performances reveals the skill behind apparently effortless communication between performer and audience. Applying TAMS to two stand-up comedy tours uncovered structural features at the macro- and microlevels, including consistently placed novel material at the beginning of shows and sections dedicated to tightly timed repeated material. TAMS also provides a new frame of reference for examining audience-performer dynamics through speech microtiming and laughter. TAMS can be applied to other forms of repeated speech, such as political stump speeches, as well as extended to other types of performance, such as dance.
Related Concept Videos
Sign Test for Matched Pairs
To conduct the sign test, we first calculate the differences in...
Protein Dynamics in Living Cells
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...
Wilcoxon Signed-Ranks Test for Matched Pairs
Protein and Protein Structure
A protein's shape is critical to its function. For example, an enzyme...
Cis-regulatory Sequences
Additional Subnuclear Structures
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles,...

