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Is Bariatric Surgery at Risk Due to Semaglutide?

Jane Tian1, Shubham Bhatia1, Christina Sneed2

  • 1Department of General Surgery, Flushing Hospital Medical Center, Flushing, NY, USA.

Journal of Metabolic and Bariatric Surgery
|January 22, 2026
PubMed
Summary
This summary is machine-generated.

Semaglutide use in bariatric patients may reduce surgery rates, as some patients achieve significant weight loss and no longer qualify. Further research is needed on long-term weight maintenance and clinical impact.

Keywords:
Bariatric surgeryObesityOzempicSemaglutideWeight loss

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Area of Science:

  • Metabolic and Bariatric Surgery
  • Pharmacological Interventions for Obesity

Background:

  • Obesity is a major public health concern in Western countries, linked to diabetes and hypertension.
  • Semaglutide, approved for weight management, has demonstrated effectiveness but its effect on bariatric surgery is unclear.

Purpose of the Study:

  • To evaluate the impact of preoperative semaglutide use on bariatric surgery outcomes.
  • To compare patients on semaglutide versus those not using it regarding surgical candidacy and outcomes.

Main Methods:

  • Retrospective analysis of 515 bariatric patients (January 2022 - November 2023).
  • Comparison of patients on semaglutide versus controls, analyzing time to surgery, cancellation rates, weight loss, and side effects.

Main Results:

  • Semaglutide users had higher diabetes rates but comparable preoperative weights.
  • Patients on semaglutide were less likely to proceed with surgery (22% lost qualification due to weight loss).
  • Post-surgery weight loss at 2 and 6 months was similar between groups.

Conclusions:

  • Semaglutide may decrease bariatric surgery volume and delay interventions.
  • Long-term weight maintenance and clinical implications of semaglutide require further study.