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Copper-Based Nanozymes for Tumor Therapy: Structural Design and Combination Strategies.

Ziqiang Sun1, Mingxiao Shao1, Liyan Qiu1

  • 1Ministry of Education (MOE) Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310058, China.

ACS Applied Materials & Interfaces
|January 22, 2026
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Summary
This summary is machine-generated.

Copper-based nanozymes (CuNZs) mimic natural enzymes for cancer therapy by regulating reactive oxygen species (ROS) in the tumor microenvironment. Optimizing CuNZ design enhances efficacy and selectivity, offering new treatment avenues.

Keywords:
cancer therapycopper-based nanozymesenzymatic activityreactive oxygen speciesstructure−activity relationship

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Cancer Research

Background:

  • Copper-based nanozymes (CuNZs) are emerging functional nanomaterials with tunable catalytic properties.
  • CuNZs can mimic various natural enzymes, including oxidase, peroxidase, superoxide dismutase, and catalase.
  • These properties are crucial for regulating the tumor microenvironment (TME) in cancer therapy.

Purpose of the Study:

  • To review the enzymatic activities of CuNZs.
  • To explore their applications in cancer treatment.
  • To analyze factors influencing CuNZ catalytic performance.

Main Methods:

  • Literature review of studies on CuNZs in cancer therapy.
  • Analysis of enzymatic activities (oxidase, peroxidase, SOD, catalase mimicry).
  • Investigation of structure-activity relationships (size, morphology, valence, surface modification).

Main Results:

  • CuNZs demonstrate significant potential in inhibiting tumor progression by regulating ROS in the TME.
  • Factors like size, morphology, valence state, and surface modification critically influence CuNZ catalytic performance.
  • CuNZs offer a promising strategy to overcome resistance and reduce side effects of traditional cancer treatments.

Conclusions:

  • Optimized CuNZ design can enhance therapeutic efficacy and selectivity.
  • CuNZs show potential for multimodal combination therapy in cancer treatment.
  • Further research into CuNZs promises more effective and precise cancer therapeutic solutions.