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Comparison of Hyperbaric Ropivacaine and Hyperbaric Bupivacaine in Subarachnoid Block: A Meta-analysis
Gaurav Acharya1, Shivani Badal2, Tushar Kumar3
1Department of Anaesthesia and Critical Care, Bhopal Memorial Hospital and Research Centre, Bhopal, Madhya Pradesh, India.
Annals of African Medicine
|January 22, 2026
Summary
Hyperbaric ropivacaine offers a faster recovery with shorter sensory and motor blockade durations compared to hyperbaric bupivacaine. This meta-analysis highlights ropivacaine
Area of Science:
- Anesthesiology
- Pharmacology
- Clinical Trials
Background:
- Hyperbaric ropivacaine is a new option for subarachnoid blocks in India.
- Hyperbaric bupivacaine is the standard local anesthetic for these procedures.
- A comparative analysis of these two agents is warranted.
Purpose of the Study:
- To compare hyperbaric ropivacaine and hyperbaric bupivacaine in subarachnoid blocks.
- To evaluate differences in sensory and motor blockade onset and duration.
- To assess the incidence of associated complications.
Main Methods:
- A meta-analysis of randomized control trials was conducted.
- Searched Cochrane, PubMed, and Google Scholar databases.
- Included studies compared hyperbaric ropivacaine and hyperbaric bupivacaine without adjuvants.
Main Results:
- Hyperbaric ropivacaine demonstrated significantly shorter motor (37.09 hours) and sensory (38.83 hours) blockade durations.
- Reduced incidence of hypotension and bradycardia observed with ropivacaine.
- 18 studies were included in the meta-analysis.
Conclusions:
- Hyperbaric ropivacaine provides a shorter duration of sensory and motor blockade.
- This suggests a faster recovery profile for patients receiving ropivacaine.
- Ropivacaine may be a favorable alternative to bupivacaine for subarachnoid blocks.
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