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Updated: Jan 23, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Mechanochemically Triggered Deaminative Halogenation of Anilines Mediated by a TEMPO-Driven Radical Manifold
1College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
Abstract:
Under ball-milling, continuous mechanical energy enables a TEMPO-mediated single-electron process, while inexpensive ferric nitrate serves as the nitrogen source for in situ diazotization. This method rapidly converts anilines into aryl halides with broad functional-group tolerance, avoiding hazardous diazonium salts, external heating, and bulk solvents. The approach improves operational simplicity, atom economy, and sustainability, highlighting the power of mechanochemistry to promote redox-driven transformations and providing a practical alternative to conventional solution-phase halogenation.
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