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Nanozyme-based therapeutics: bridging catalysis and nanomedicine
Abhay Thakur1, Rohit Sharma2, Rahul Sharma3
1School of Pharmaceutical and Health Science, Career Point University, Hamirpur, India.
Pharmaceutical Development and Technology
|January 22, 2026
Summary
Nanozymes, engineered nanoparticles with enzyme-like activity, show promise for nanomedicine. Further research is needed to address safety and manufacturing challenges for clinical translation.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Catalysis
Background:
- Nanozymes are engineered nanoparticles mimicking natural enzyme catalysis.
- They offer potential in bioanalytical and biomedical applications due to their tunable properties.
- Recent research focuses on mechanistic understanding and biological activity.
Purpose of the Study:
- To review recent advances in nanozyme research.
- To emphasize mechanistic understanding over strict kinetic equivalence to enzymes.
- To discuss applications, challenges, and future directions in nanomedicine.
Main Methods:
- Review of recent literature on nanozyme research.
- Discussion of fundamental catalytic principles (electron transfer, redox cycling).
- Analysis of structural features, surface functionalization, and stimuli-responsiveness.
Main Results:
- Nanozymes exhibit enzyme-comparable activity with optimization.
- Structural and surface properties significantly influence nanozyme activity.
- Tumor microenvironment-responsive nanozymes enable targeted redox modulation.
- Pharmacokinetics and biosafety remain critical areas for evaluation.
Conclusions:
- Nanozymes are versatile catalytic platforms with significant potential in nanomedicine.
- Mechanistic understanding, standardized evaluation, and safety assessments are crucial for translation.
- Addressing challenges in synthesis, reproducibility, and regulatory compliance is essential.
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