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Related Concept Videos

Transcription Elongation Factors02:35

Transcription Elongation Factors

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Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...
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The Eukaryotic Promoter Region02:40

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The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences.  The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
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Transcription Factors

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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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IR spectra are divided into two main regions: the diagnostic region and the fingerprint region. The diagnostic region of the spectrum lies above 1500 cm−1. The absorptions resulting from single-bond vibrations of the N–H, C–H, and O–H stretch at higher wavenumbers and appear on the left side of the spectrum. The stretching absorptions of the C≡C and C≡N occur between 2100–2300 cm−1. In contrast, those arising from stretching absorptions of the...
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Association Areas of the Cortex01:21

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Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
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Associative learning is a fundamental concept in behavioral psychology, wherein a connection is established between two stimuli or events, leading to a learned response. This process is critical in understanding how behaviors are acquired and modified. Conditioning, the mechanism through which associations are formed, can be divided into two main types: classical conditioning and operant conditioning, each elucidating different aspects of associative learning.
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Related Experiment Video

Updated: Jan 23, 2026

Author Spotlight: Exploring the Role of FAM83A in Cervical Cancer
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Associations Between Regional Factors and Cervical Cancer Screening Coverage in Tokyo.

Iori Harada1, Yuri Ito2, Kumiko Morita1

  • 1Department of Public Health Nursing, Insititute of Science, Tokyo, Japan.

Asian Pacific Journal of Cancer Prevention : APJCP
|January 22, 2026
PubMed
Summary

Cervical cancer screening coverage in Tokyo varies significantly by region. Improving access to screening facilities, simplifying appointments, and integrating HPV testing can increase participation rates.

Keywords:
Cervical cancerHuman papillomavirus testingRegional variationhealth accessibilityscreening coverage

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Area of Science:

  • Public Health
  • Oncology
  • Epidemiology

Background:

  • Cervical cancer incidence is rising in Japan, yet screening coverage remains low.
  • Regional disparities in screening coverage are not well understood.

Purpose of the Study:

  • To analyze regional variations in cervical cancer screening coverage in Tokyo.
  • To identify regional factors influencing screening coverage.

Main Methods:

  • Retrospective ecological study using 2018 data from 53 Tokyo municipalities.
  • Data sources included public health statistics, census data, and municipal websites.
  • Linear regression analysis examined associations between screening coverage and factors like healthcare access, workforce demographics, and testing methods.

Main Results:

  • Mean screening coverage in Tokyo was 18.6% (range: 8.1-85.8%).
  • Key factors associated with higher coverage included more screening facilities per capita, a higher proportion of working women, and inclusion of HPV testing.
  • Requirement for appointments was negatively associated with coverage.

Conclusions:

  • Enhancing screening accessibility, simplifying appointment processes, and incorporating HPV testing are crucial for improving cervical cancer screening coverage.
  • Findings offer insights for developing targeted public health policies and local screening strategies.