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Updated: Jan 24, 2026

Anterior Cervical Discectomy and Fusion in the Ovine Model
Published on: October 5, 2009
Predictors of achieving Neck Disability Index minimum clinically important difference following cervical deformity
Anthony L Mikula1, Justin K Scheer2, Rahul Kumar3
11Department of Neurological Surgery, University of California, San Francisco.
Predictors of minimum clinically important difference (MCID) in Neck Disability Index (NDI) after cervical spinal deformity surgery include baseline NDI, C2-7 sagittal vertical axis change, depression, and Charlson Comorbidity Index. These factors aid in predicting patient outcomes.
Area of Science:
- Spine Surgery
- Orthopedics
- Clinical Outcomes Research
Background:
- Cervical spinal deformity surgery aims to improve patient function and quality of life.
- The Neck Disability Index (NDI) is a common patient-reported outcome measure.
- Identifying predictors of the minimum clinically important difference (MCID) is crucial for understanding surgical success.
Purpose of the Study:
- To determine predictors of achieving the MCID in the NDI after cervical spinal deformity surgery.
- To identify patient and radiographic factors associated with meaningful improvement in neck function.
Main Methods:
- Retrospective review of a prospective, multicenter adult cervical spinal deformity database.
- Analysis of baseline and 1-year NDI scores to define MCID (7-point improvement).
- Univariate and multivariable logistic regression analyses of demographics, comorbidities, and spinopelvic parameters.
Main Results:
- 59% of 122 patients achieved NDI MCID at 1 year.
- Univariate predictors included lower Charlson Comorbidity Index (CCI), depression, lower C2 tilt, and greater C2-7 sagittal vertical axis (SVA) change.
- Multivariable analysis identified lower CCI, depression, greater C2-7 SVA change, and baseline NDI as significant predictors.
Conclusions:
- Higher baseline NDI, greater C2-7 SVA change, patient-reported baseline depression, and lower CCI predict NDI MCID.
- These factors can help anticipate functional recovery following cervical spinal deformity surgery.
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