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Related Experiment Video

Updated: Jan 24, 2026

In Vitro and In Vivo Approaches to Determine Intestinal Epithelial Cell Permeability

In Vitro and In Vivo Approaches to Determine Intestinal Epithelial Cell Permeability

Published on: October 19, 2018

Neuronal VIP wires the intestinal epithelial cell function.

Ziad Al Nabhani¹, Valentin Thevin¹, Luisa Morelli¹

¹Department of Visceral Surgery and Medicine, Bern University Hospital, Bern, Switzerland; Maurice Müller Laboratories, Department for Biomedical Research, University of Bern, Bern, Switzerland.

Mucosal Immunology

|January 22, 2026

Summary

Neuron-derived vasoactive intestinal peptide (VIP) regulates gut health by controlling intestinal cell development and immune balance. This peptide-receptor interaction preserves the gut barrier and influences immunity.

Keywords:

Enteric neurons Intestinal epithelial cells Type 2 immunity VIP

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Published on: January 5, 2017

Area of Science:

Immunology
Neuroscience
Gastroenterology

Background:

The gut epithelium and immune system are crucial for maintaining intestinal homeostasis.
Neural regulation of gut functions is increasingly recognized but not fully understood.

Purpose of the Study:

To investigate the role of neuron-derived vasoactive intestinal peptide (VIP) in regulating intestinal epithelial differentiation.
To elucidate how VIP orchestrates immune responses within the gut.
To understand the mechanisms by which VIP contributes to gut barrier integrity.

Main Methods:

Utilized mouse models to study the effects of VIP signaling in the intestine.
Investigated gene expression and cellular differentiation in the intestinal epithelium.
Analyzed immune cell populations and cytokine profiles.
Examined the function of the VIP receptor, VIPR1.

Main Results:

Neuron-derived VIP restrains the expansion of secretory cell lineages in the intestinal epithelium.
VIP signaling, via VIPR1, balances type 1 and type 2 immune responses.
VIP establishes a neuro-epithelial circuit that is critical for preserving gut barrier integrity.

Conclusions:

Neuron-derived VIP is a key regulator of intestinal epithelial differentiation and immune homeostasis.
VIP plays a vital role in maintaining gut barrier function through a neuro-epithelial circuit.
Targeting VIP signaling may offer therapeutic potential for inflammatory and barrier-related gut disorders.