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Updated: Jan 24, 2026

In Vitro and In Vivo Approaches to Determine Intestinal Epithelial Cell Permeability
Published on: October 19, 2018
Neuronal VIP wires the intestinal epithelial cell function
Ziad Al Nabhani1, Valentin Thevin1, Luisa Morelli1
1Department of Visceral Surgery and Medicine, Bern University Hospital, Bern, Switzerland; Maurice Müller Laboratories, Department for Biomedical Research, University of Bern, Bern, Switzerland.
Abstract:
Two studies in Nature Immunology by Jakob, Sterczyk et al. and Pirzgalska et al. show that neuron-derived vasoactive intestinal peptide (VIP) regulates intestinal epithelial differentiation and orchestrates immune responses. Through its receptor VIPR1, VIP restrains secretory lineage expansion, balances type 1 and type 2 immunity, and establishes a neuro-epithelial circuit preserving gut barrier integrity.
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