Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vaccinations01:51

Vaccinations

51.3K
Overview
51.3K
Preparedness and Phobias01:09

Preparedness and Phobias

333
Human fear responses to certain stimuli, such as darkness, heights, deep water, and blood, can often arise despite the absence of direct negative experiences. This phenomenon is rooted in evolutionary psychology, which posits that humans have developed a predisposition to fear stimuli that historically posed significant survival threats. This predisposition, known as preparedness, suggests that early humans who developed a fear of potentially dangerous entities, such as venomous snakes and...
333
Design Example: Strain Gauge Bridge or Wheatstone Bridge01:15

Design Example: Strain Gauge Bridge or Wheatstone Bridge

977
The utilization of strain gauges as transducers for converting mechanical strain into electrical signals is a common practice in various engineering applications. These strain gauges are frequently integrated into Wheatstone bridge circuits to accurately measure parameters such as force or pressure. Within this context, each element within the circuit exhibits a resistance that undergoes subtle variations when subjected to mechanical strain. The primary objective is to convert minuscule...
977
Bridge rectifier01:24

Bridge rectifier

1.5K
The bridge rectifier is essential in electronics for efficiently converting alternating current (AC) to direct current (DC). Comprised of four diodes configured in a bridge layout, this rectifier effectively processes both the positive and negative halves of the AC waveform, making it superior to half-wave and full-wave center-tapped rectifiers in terms of voltage regulation and output stability.
Operationally, the bridge rectifier allows current flow through two of its diodes during each...
1.5K
Wheatstone Bridge01:29

Wheatstone Bridge

1.2K
An ohmmeter is a resistance-measuring device. It works by applying a voltage to a resistor of unknown resistance and measuring the current across the resistor. The resistance value is deduced using Ohm's law. Usually, the standard configuration of an ohmmeter comprises a voltmeter or an ammeter. However, such configurations are limited in accuracy because the meters alter the voltage applied to the resistor and the current that flows through it.
Thus, for accurate resistance measurements, a...
1.2K
Cross-bridge Cycle01:26

Cross-bridge Cycle

122.4K
As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
122.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunogenicity and protective efficacy on non-adjuvanted CD40-targeting SARS-CoV-2 vaccines in non-human primates.

EBioMedicine·2026
Same author

Cross-reactive Bundibugyo antibody responses after licensed Ebola vaccines.

medRxiv : the preprint server for health sciences·2026
Same author

Gene set analysis for time-to-event outcome: comparison of a new approach based on the generalized Berk-Jones statistic with existing methods in presence of intra gene-set correlation.

Briefings in bioinformatics·2026
Same author

CD40.HIVEnv, an antibody mediated vaccine, induces long-term and recall immunogenicity in non-HIV-1 infected volunteers.

Scientific reports·2026
Same author

Incidence and risk factors of <i>C. trachomatis</i>, <i>N. gonorrhoeae</i> and syphilis among a cohort of urban Canadian gay, bisexual and other men who have sex with men, 2017-2023: informing the potential impact of doxycycline prophylaxis.

BMJ open·2026
Same author

Characteristics and outcomes of patients with HER2-negative metastatic breast cancers with low expression of estrogen and progesterone receptors in the multicenter ESME cohort.

Breast (Edinburgh, Scotland)·2026

Related Experiment Video

Updated: Jan 24, 2026

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

11.2K

Defining Optimal Vaccine Features for Pandemic Preparedness: an Individual-Based Model Bridging Within- and

Yiqing Xia1, Marie Alexandre2,3,4, Rodolphe Thiebaut2,3,4,5

  • 1Department of Epidemiology and Biostatistics, School of Population and Global Health, McGill University, Montréal, QC, Canada.

Bulletin of Mathematical Biology
|January 22, 2026
PubMed
Summary
This summary is machine-generated.

Developing effective vaccines for future pandemics is crucial. This study highlights that prioritizing vaccine efficacy (EC50) and long-term immunity is key to controlling outbreaks and reducing hospitalizations.

Keywords:
100 day missionCoronavirusDisease XMathematical modellingSevere acute respiratory syndrome (SARS)Vaccine

More Related Videos

Author Spotlight: Streamlining Visual Dynamics to Simplify Molecular Dynamics Simulations Using Gromacs
05:00

Author Spotlight: Streamlining Visual Dynamics to Simplify Molecular Dynamics Simulations Using Gromacs

Published on: August 9, 2024

1.9K
Spotting Cheetahs: Identifying Individuals by Their Footprints
09:47

Spotting Cheetahs: Identifying Individuals by Their Footprints

Published on: May 1, 2016

15.3K

Related Experiment Videos

Last Updated: Jan 24, 2026

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

11.2K
Author Spotlight: Streamlining Visual Dynamics to Simplify Molecular Dynamics Simulations Using Gromacs
05:00

Author Spotlight: Streamlining Visual Dynamics to Simplify Molecular Dynamics Simulations Using Gromacs

Published on: August 9, 2024

1.9K
Spotting Cheetahs: Identifying Individuals by Their Footprints
09:47

Spotting Cheetahs: Identifying Individuals by Their Footprints

Published on: May 1, 2016

15.3K

Area of Science:

  • Epidemiology
  • Vaccinology
  • Mathematical Modeling

Background:

  • Future pandemic preparedness requires proactive surveillance and prototype vaccine development.
  • The
  • 100 Day Mission
  • emphasizes equitable vaccine access.

Purpose of the Study:

  • Identify optimal vaccine features for controlling future pathogen outbreaks, such as SARS-CoV-2.
  • Examine the impact of vaccine characteristics on infection and hospitalization rates.
  • Evaluate vaccine development priorities for pandemic response.

Main Methods:

  • Developed an individual-based transmission model integrating viral load and antibody kinetics.
  • Simulated a population of 10,000 over 18 months with vaccination starting on Day 100.
  • Analyzed combinations of basic reproduction number (R0) and vaccine features (EC50, half-life, infection rate impact).

Main Results:

  • Vaccines similar to BNT162b2 averted 23-47% of cases and 32-61% of hospitalizations.
  • Lowering EC50 and extending plasma-secreting cell half-life reduced transmission, with diminishing returns.
  • Vaccine allocation strategy had minimal impact on population-level outcomes.

Conclusions:

  • Prioritize improving vaccine efficacy (EC50) for future pandemic vaccine development.
  • Increasing long-term immunity (plasma-secreting cell half-life) is the second most important factor.
  • Modifying virus-target cell infection rate had minimal impact on population outcomes.