Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What are Lipids?01:38

What are Lipids?

219.4K
Overview
219.4K
What are Lipids?01:31

What are Lipids?

10.8K
Lipids function as structural components of cellular membranes, in addition to acting as energy reservoirs and signaling molecules. They are thus crucial to all living organisms.  The three biologically important classes of lipids are triglycerides, phospholipids, and steroids.
Non-Polar and Hydrophobic Characteristics of Lipids
Lipids are a structurally and functionally diverse group of hydrocarbons—compounds consisting of carbon and hydrogen atoms. The carbon-carbon and...
10.8K
Lipid Digestion01:06

Lipid Digestion

99.0K
Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
99.0K
Sustainable Development01:43

Sustainable Development

14.8K
As the human population continues to grow and use resources, we must be mindful of our planet’s natural limits. Sustainable development provides a pathway to maintain and improve human life now while also ensuring that future generations will have the resources that they need. The long-term success of sustainability efforts rests on understanding the interplay between human actions and ecological systems.
14.8K
Structure of Lipids03:38

Structure of Lipids

98.5K
Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic...
98.5K
Characteristics of Practical Op Amps01:16

Characteristics of Practical Op Amps

839
A difference amplifier, a crucial component in numerous electronic devices, ideally amplifies only the difference-mode signal, which is the difference between two input signals. However, in practical circuits, the output voltage depends on both the differential gain and the common-mode gain.
The ratio of differential gain to the common-mode gain is defined as the common-mode rejection ratio (CMRR). This ratio quantifies the ability of operational amplifiers (op-amps) to reject common-mode...
839

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of Mixing Approach and Bubble Formation on In Situ Forming Implant Properties.

Pharmaceutical research·2026
Same author

Evolving Landscape of Glioblastoma Research: Integrating Therapeutic Advances and Diagnostic Frontiers.

Brain sciences·2026
Same author

Targeting the NAD<sup>+</sup>-PARP1-XRCC1 axis in ALS.

Trends in molecular medicine·2026
Same author

Exploring the impact of nucleotide length on lipid nanoparticle structure and properties.

International journal of pharmaceutics·2026
Same author

A nanovaccine induces durable and functional MUC4-targeted T cell responses against pancreatic cancer.

Acta biomaterialia·2026
Same author

Peripheral vaccination-induced brain-resident memory CD8+ T cells durably protect mice against intracranial malignancy.

The Journal of clinical investigation·2026

Related Experiment Video

Updated: Jan 24, 2026

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform
09:41

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

Published on: February 25, 2021

25.1K

Lipid Nanoparticle Development in Practice: Challenges and Collective Insights.

Xiuling Lu1, Sheyda Ranjbar2, Fan Zhang3

  • 1Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, 06269, USA. xiuling.lu@uconn.edu.

Pharmaceutical Research
|January 22, 2026
PubMed
Summary
This summary is machine-generated.

Lipid nanoparticles (LNPs) are advanced drug delivery systems. Understanding LNP quality, formulation, and design is crucial for developing effective therapeutics and ensuring clinical success.

Keywords:
characterizationdrug deliverylipid nanoparticlescale upstability

More Related Videos

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications
08:19

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications

Published on: November 17, 2015

18.6K
Tethered Bilayer Lipid Membranes to Monitor Heat Transfer between Gold Nanoparticles and Lipid Membranes
07:33

Tethered Bilayer Lipid Membranes to Monitor Heat Transfer between Gold Nanoparticles and Lipid Membranes

Published on: December 8, 2020

3.0K

Related Experiment Videos

Last Updated: Jan 24, 2026

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform
09:41

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

Published on: February 25, 2021

25.1K
Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications
08:19

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications

Published on: November 17, 2015

18.6K
Tethered Bilayer Lipid Membranes to Monitor Heat Transfer between Gold Nanoparticles and Lipid Membranes
07:33

Tethered Bilayer Lipid Membranes to Monitor Heat Transfer between Gold Nanoparticles and Lipid Membranes

Published on: December 8, 2020

3.0K

Area of Science:

  • Biotechnology
  • Nanomedicine
  • Drug Delivery Systems

Background:

  • Lipid nanoparticles (LNPs) are key delivery platforms enhancing drug pharmacokinetics and enabling targeted delivery.
  • Advancing LNP therapeutics necessitates understanding the interplay of raw material quality, formulation, architecture, and biological factors.

Purpose of the Study:

  • To provide insights into challenges and lessons learned in LNP development.
  • To emphasize critical factors for the next generation of LNP technologies.

Main Methods:

  • Discussion of characterization strategies for LNPs.
  • Exploration of delivery specificity, scale-up, and long-term stability.
  • Integration of artificial intelligence in LNP development.

Main Results:

  • Key challenges in LNP development were identified.
  • Practical insights and lessons learned from ongoing LNP efforts were shared.
  • The importance of rational design, manufacturing, and characterization was highlighted.

Conclusions:

  • Robust manufacturing, comprehensive characterization, and rational design are vital for LNP advancement.
  • Innovative approaches, including AI, are essential for next-generation LNP therapeutics.
  • A deeper understanding of LNP influencing factors is critical for clinical performance.