Incidents and Adverse Events Associated With Peripherally Inserted Central Catheters in Neonatology: A Scoping Review

Peripherally inserted central catheters (PICCs) are essential in neonatal intensive care units for prolonged venous access. Despite their benefits, PICCs are associated with multiple complications. This scoping review mapped incidents and adverse events related to PICC use in neonates.

The protocol was registered on the Open Science Framework (DOI: 10.17605/OSF.IO/HKU4C). The review followed the Joanna Briggs Institute methodology and PRISMA-ScR guidelines. Searches were conducted in PubMed, EMBASE, Scopus, LILACS, BDENF, WPRO, Cochrane Library, Google Scholar, and OATD, including gray literature and reference lists. Eligibility criteria were defined using the PCC (Population, Concept, Context) framework. Two independent reviewers screened and selected studies.

From 569 records, 24 studies met the criteria. Thirty-four types of incidents and adverse events were identified, most frequently catheter occlusion, bloodstream infection, mechanical damage, displacement, phlebitis, thrombosis, and accidental removal. The included studies varied by country, design, and sample size, with a predominance of retrospective and descriptive approaches.

Peripherally inserted central catheter use in neonates carries risks that require systematic monitoring and preventive strategies. The evidence mapping highlights the need for standardized protocols and interdisciplinary training to strengthen neonatal patient safety.