Related Experiment Video
Updated: Jan 24, 2026
Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study
Published on: April 18, 2025
The Role of Polyunsaturated Fatty Acids in Combating Cardiovascular Inflammation: A Bibliometric and Visual Analysis
Yalin Huang1, Zhuoyi Zhang1, Tianzhang Zhang1
1Department of Cardiology, Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian 362000, China.
Introduction:
This study aimed to explore the current status, hotspots, and trends in research on polyunsaturated fatty acids (PUFAs) and cardiovascular inflammation.
Methods:
Literature related to cardiovascular inflammation and PUFAs from the Web of Science Core Collection between January 1, 2009, and July 1, 2024, was retrieved using specific search terms, and the data were visualized and analyzed using CiteSpace (version 6.3.R3) and VOSviewer (version 1.6.20).
Results And Discussion:
PUFAs and cardiovascular inflammation publications have been found to grow over the past 15 years. The United States leads in this field, with Nutrients being the leading journal. Harvard University and the University of California system are the most influential institutions. Most publications are in immunology and medical journals, while citations are primarily in biology and nutrition journals. International collaboration is strong, with Mozaffarian and Calder making significant contributions. Bhatt et al. and Bosch et al. have the most citations and the highest centrality, respectively. Research trends focus on the relationship between PUFAs and inflammatory markers, the anti-inflammatory mechanisms of PUFAs, and their association with diseases. Omega-3 and omega-6 PUFAs show divergent impacts on inflammation and cardiovascular diseases (CVD) risk, with gut microbiota mediating bidirectional regulation. Emerging research directions in PUFAs' anti-inflammatory mechanisms encompass gut microbiota, oxidative stress, and pro-resolving mechanisms, with gut microbiota as the current focus.
Conclusion:
This bibliometric analysis has highlighted sustained growth and global collaboration in PUFAs-cardiovascular inflammation research. Key emerging mechanisms have been found to focus on the gut-microbiota-PUFAs axis, oxidative stress, and pro-resolving pathways, pointing towards future translational opportunities.
Related Concept Videos
01:28Overview of Fatty Acid Metabolism
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
01:38Inflammation
01:14Overview of the Cardiovascular System
Heart
The heart is the central pump of the cardiovascular system that circulates blood throughout the body. It comprises two atria receiving the blood and two ventricles pumping blood out of the heart. Their rhythmic contractions, called heartbeats, ensure that blood flow remains continuous.
Blood Vessels
Blood...
01:27Regulation of the Cardiovascular System
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
01:20Exercise and Cardiovascular Response
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
01:27Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...