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Published on: January 24, 2013
Anemia, inflammation, circadian rhythm and season effects in febrile convulsions
Ilknur Surucu Kara1,2, Necla Aydin Peker2, Yusuf Kemal Arslan3
1Department of Pediatric Metabolism, Gaziantep City Hospital Faculty of Medicine, Gaziantep, Turkiye.
Insights
Young age, anemia, inflammation, and hypocapnia may contribute to febrile convulsions in children. Hemogram parameters like MPV and NLR may indicate inflammation, aiding in etiology elucidation.
Area of Science:
- Pediatrics
- Neurology
- Hematology
Background:
- Febrile convulsions are common in children.
- Understanding contributing factors is crucial for diagnosis and management.
Purpose of the Study:
- To investigate circadian rhythm, season, age, gender, and hemogram parameters in children with febrile convulsions.
- To identify potential indicators of inflammation and hypocapnia.
Main Methods:
- A comparative study involving 160 children with febrile convulsions and 318 healthy controls.
- Analysis of demographic data, hemogram parameters (MPV, lymphocyte count, NLR), and blood gases.
Main Results:
- Younger age was associated with higher lymphocyte count and lower NLR.
- Patients with febrile convulsions showed lower MPV and higher NLR compared to controls.
- Anemia was linked to lower NLR in both patient and control groups.
- One-third of patients exhibited hypocapnia.
Conclusions:
- Young age, anemia, inflammation, and hypocapnia may predispose children to febrile convulsions.
- MPV and NLR can serve as markers for inflammation.
- Blood gas analysis may help identify hypocapnia, aiding in etiological understanding.
Objective:
Our aim in the study is to investigate circadian rhythm, season, age, gender, and hemogram parameters in children diagnosed with febrile convulsions.
Methods:
The data of a total of 478 children, consisting of 160 patients with febrile convulsions (90 male/70 female) and 318 control groups (healthy, convulsiyon free- febrile), were compared.
Results:
The average age of all patients was 25.7±14.7 (minimum 6-maximum 60) months, and the most common convulsion age was 13-18 months. Circadian rhythm was similar, application seasons were similar. The male/female ratio was 1.3. MPV in winter was lower than other seasons (p=0.002). At younger ages, lymphocyte count was higher (p=0.048) and NLR was lower (p=0.036). NLR was lower in patients with febrile convulsions with anemia than in patients with febrile convulsions without anemia (p=0.029). NLR was lower in patients with febrile convulsions with anemia than in the convulsion-free febrile control group with anemia (p=0.001). In patients with febrile convulsions, MPV was lower (p=0.033) and NLR was higher (p=0.001) than in the convulsion-free febrile control group. One third of the patients had hypocapnia.
Conclusion:
Young age, anemia, inflammation, and hypocapnia may facilitate the occurrence of febrile convulsions. MPV and NLO, which are hemogram parameters, can guide us about inflammation. Blood gases may provide information regarding hypocapnia. These rapid examinations may help elucidate the etiology. Prospective studies are needed for circadian rhythm in febrile convulsions.
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