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Antiseizure Treatments and Liver Injury: Expect (and Prevent) the Unexpected
Marjorie Bunch1, Shilpa Klocke2, Nicole Woodrich3
1Department of Neurology, Albany Medical College, Albany, NY, USA.
None:
Drug-induced liver injury remains a major concern in the pharmacological management of epilepsy. Antiseizure medication (ASM)-related liver injury has multiple phenotypes, and in the majority of cases it is "idiosyncratic," involving hypersensitivity reactions. Awareness of drug- and patient-related risk factors can help direct treatment selection, monitoring, and ASM discontinuation, when necessary. This article examines the typical patterns of ASM-induced liver injury, from mild elevations of hepatic enzymes to life-threatening conditions. We also discuss risk factors, means for preventing liver injury in people with epilepsy treated with ASMs, and emerging biomarkers.
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