Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Spinal Cord01:26

Spinal Cord

1.6K
The spinal cord, a critical component of the central nervous system, extends from the base of the brainstem to the lumbar region of the vertebral column. It is essential for maintaining physical stability and facilitating communication between the brain and peripheral parts of the body.
1.6K
The Spinal Cord01:54

The Spinal Cord

31.6K
The spinal cord is the body’s major nerve tract of the central nervous system, communicating afferent sensory information from the periphery to the brain and efferent motor information from the brain to the body. The human spinal cord extends from the hole at the base of the skull, or foramen magnum, to the level of the first or second lumbar vertebra.
31.6K
Spinal Cord: Information Processing01:10

Spinal Cord: Information Processing

3.3K
The spinal cord is an integral hub for motor and sensory information that enables the brain to communicate with the peripheral nervous system (PNS). This communication consists of relaying sensory data and transmission of motor commands.
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
3.3K
Spinal Cord: Gross Anatomy01:15

Spinal Cord: Gross Anatomy

5.5K
The spinal cord resides within the protective confines of the vertebral column. It is the main pathway for information traveling between the brain and the body. It plays a fundamental role in nearly all bodily functions, from simple reflexes to complex motor movements. The spinal cord begins at the medulla oblongata at the base of the brainstem and extends downward, terminating at the conus medullaris near the first and second lumbar vertebrae. The spinal cord's length in adults is...
5.5K
Spinal Cord: Cross-sectional Anatomy01:16

Spinal Cord: Cross-sectional Anatomy

4.5K
The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
4.5K
Stimulants01:29

Stimulants

875
Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
875

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beyond Exposure: Standardizing Buprenorphine Training in Pain Medicine Fellowship.

Psychopharmacology bulletin·2026
Same author

Discrepancies in Urine Drug Screening Among Patients Receiving Chronic Opioid Therapy for Non-Cancer Pain: A Retrospective Review.

Current pain and headache reports·2026
Same author

Smoking Status Among Patients Presenting to a Chronic Pain Clinic: A Retrospective Review from a University-Affiliated Pain Clinic.

Psychopharmacology bulletin·2026
Same author

Suzetrigine for Pain Management: An Observational Study of Early Adoption Patterns.

Psychopharmacology bulletin·2026
Same author

Improved Pain and Function Using Multiphase Spinal Cord Stimulation in a Nonsurgical Spine Patient.

Orthopedic reviews·2026
Same author

Tramadol Utilization Patterns: A One-Year Retrospective Review.

Psychopharmacology bulletin·2026

Related Experiment Video

Updated: Jan 24, 2026

Paradigms of Lower Extremity Electrical Stimulation Training After Spinal Cord Injury
08:07

Paradigms of Lower Extremity Electrical Stimulation Training After Spinal Cord Injury

Published on: February 1, 2018

13.2K

Functional Recovery Following Spinal Cord Stimulation in a Patient Utilizing Prospera Spinal Cord Stimulation System

Jamal Hasoon1, Ivan Urits2

  • 1Department of Anesthesiology, Critical Care, and Pain Medicine The University of Texas Health Science Center at Houston.

Orthopedic Reviews
|January 23, 2026
PubMed
Summary

Spinal cord stimulation (SCS) effectively reduced severe neuropathic pain and improved function in a patient with debilitating lumbar radiculopathy after failed surgery. This treatment enabled significant pain relief and restored mobility, even in severe cases.

Keywords:
Chronic painLumbar radiculopathyMultiphase stimulationNeuromodulationProspera SCS systemSpinal cord stimulation

More Related Videos

Author Spotlight: Advancing Spinal Cord Stimulation - Exploring the Cellular Responses of Motor Neurons Through Patch-Clamp Electrophysiology
06:55

Author Spotlight: Advancing Spinal Cord Stimulation - Exploring the Cellular Responses of Motor Neurons Through Patch-Clamp Electrophysiology

Published on: September 8, 2023

3.6K
The Preparation of Oblique Spinal Cord Slices for Ventral Root Stimulation
09:10

The Preparation of Oblique Spinal Cord Slices for Ventral Root Stimulation

Published on: October 13, 2016

10.2K

Related Experiment Videos

Last Updated: Jan 24, 2026

Paradigms of Lower Extremity Electrical Stimulation Training After Spinal Cord Injury
08:07

Paradigms of Lower Extremity Electrical Stimulation Training After Spinal Cord Injury

Published on: February 1, 2018

13.2K
Author Spotlight: Advancing Spinal Cord Stimulation - Exploring the Cellular Responses of Motor Neurons Through Patch-Clamp Electrophysiology
06:55

Author Spotlight: Advancing Spinal Cord Stimulation - Exploring the Cellular Responses of Motor Neurons Through Patch-Clamp Electrophysiology

Published on: September 8, 2023

3.6K
The Preparation of Oblique Spinal Cord Slices for Ventral Root Stimulation
09:10

The Preparation of Oblique Spinal Cord Slices for Ventral Root Stimulation

Published on: October 13, 2016

10.2K

Area of Science:

  • Neurology
  • Pain Management
  • Neurosurgery

Background:

  • Chronic neuropathic pain, especially lumbar radiculopathy, significantly impacts quality of life.
  • Patients often experience persistent pain despite conservative treatments and prior spine surgery.
  • Severe cases can lead to substantial disability, including wheelchair dependence and lower extremity weakness.

Purpose of the Study:

  • To report a case of successful spinal cord stimulation (SCS) in a patient with severe, refractory lumbar radiculopathy.
  • To demonstrate the efficacy of SCS in achieving pain reduction and functional recovery after failed prior interventions.
  • To highlight the use of the Biotronik Prospera system with Multiphase Stimulation.

Main Methods:

  • A 39-year-old female with severe lumbar radiculopathy and weakness post-lumbar surgery underwent an SCS trial.
  • The trial utilized the Biotronik system with Multiphase Stimulation.
  • Following a successful trial, a permanent SCS implant was performed.

Main Results:

  • The SCS trial provided over 65% pain relief, enabling ambulation with a cane.
  • Post-implantation, the patient maintained over 70% pain improvement.
  • Significant functional gains included independent ambulation for short distances and improved quality of life.

Conclusions:

  • Spinal cord stimulation is a viable treatment option for severe neuropathic pain refractory to other treatments.
  • SCS can lead to substantial pain reduction and functional restoration in patients with failed prior spine surgery.
  • Multiphase Stimulation technology may enhance outcomes in challenging pain cases.