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Local Microcirculation Level Changes During Laser Acupuncture Treatment of Rats With Osteoarthritis.

Jae Yoon Park1, Cha Kyung Youn2,3, Sang-Mi Kang2

  • 1Department of Electrical Engineering and Computer Science, DGIST, Daegu, Republic of Korea.

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Deep-tissue microcirculation measurement using diffuse speckle contrast analysis (DSCA) can indicate laser acupuncture efficacy in osteoarthritis (OA) models. Blood flow index changes correlate with treatment response and inflammation.

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blood flow index (BFI)laser acupunctureosteoarthritis

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Area of Science:

  • Biomedical Engineering
  • Osteoarthritis Research
  • Acupuncture Studies

Background:

  • Osteoarthritis (OA) is a degenerative joint disease with limited treatment options.
  • Assessing treatment efficacy, particularly for novel therapies like laser acupuncture, requires reliable biomarkers.
  • Microcirculation plays a crucial role in tissue health and inflammation.

Purpose of the Study:

  • To evaluate deep-tissue microcirculation measurement as an indicator of laser acupuncture treatment efficacy.
  • To investigate the correlation between blood flow index (BFI) changes and osteoarthritis progression/treatment response.
  • To explore the utility of spectral analysis and machine learning for classifying treatment outcomes.

Main Methods:

  • An osteoarthritis (OA) rat model was established with four groups: normal, OA, and two treatment groups (OA10, OA20) receiving different laser doses.
  • Deep-tissue microcirculation was measured using a custom diffuse speckle contrast analysis (DSCA) system near acupoints GB34 and GB39.
  • Blood flow index (BFI) was recorded at four time points (T0-T3), and spectral analysis was performed.

Main Results:

  • OA induction led to an increased BFI, which remained elevated in untreated OA rats.
  • Laser acupuncture treatment groups showed a decrease in BFI, suggesting improved microcirculation.
  • Spectral analysis identified significant changes in the myogenic wave band, and machine learning improved group classification accuracy when BFI was included.

Conclusions:

  • Deep-tissue microcirculation measurement via DSCA is a promising indicator for assessing laser acupuncture efficacy in OA.
  • Changes in BFI reflect the acute inflammatory response and anatomical indices in OA.
  • This method offers a potential non-invasive tool for monitoring treatment effectiveness in OA research.