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Fast, Robust T2-IVIM Quantitative MRI With Distortion and Motion-Corrected Multi-Echo EPI
Liam Timms1, Mustafa Utkur1, Cemre Ariyurek1
1Department of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Magnetic Resonance in Medicine
|January 24, 2026
Summary
This study introduces a faster multi-echo MRI method for accurate T2-IVIM parameter estimation. The new technique significantly reduces scan time for diffusion-weighted imaging, improving liver coverage and robustness.
Area of Science:
- Magnetic Resonance Imaging
- Diffusion-Weighted Imaging
- Quantitative MRI
Background:
- Intravoxel Incoherent Motion (IVIM) imaging provides insights into tissue microdynamics.
- T2-IVIM modeling offers compartment-specific T2 estimates, enhancing IVIM analysis.
- Robust parameter estimation is crucial for clinical translation of IVIM techniques.
Purpose of the Study:
- To develop a motion- and distortion-corrected T2-IVIM parameter estimation method.
- To achieve clinically feasible scan times for abdominal diffusion-weighted MRI.
- To enable robust estimation of T2-IVIM parameters.
Main Methods:
- Utilized a single-shot, multi-echo spin-echo EPI sequence for abdominal diffusion-weighted MRI.
- Implemented time-efficient sampling of b-value and TE pairs.
- Applied motion and distortion correction, followed by joint T2-IVIM model fitting across b-value and TE dimensions.
Main Results:
- Achieved motion- and distortion-corrected T2-IVIM mapping in under 5 minutes.
- Demonstrated comparable per-voxel uncertainty to a minimal single-echo protocol.
- Showcased improved liver coverage and reduced scan time by over 50% compared to prior protocols.
Conclusions:
- The multi-echo sequence design and artifact correction enable stable T2-IVIM fitting.
- This advanced method supports broader clinical applicability of T2-IVIM imaging.
- Reduced acquisition burden enhances artifact correction and parameter robustness for T2-IVIM.
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