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What is Natural Selection?01:32

What is Natural Selection?

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Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.
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Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
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Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.
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Total voids in concrete encompass gel water volume, capillary pores, and entrapped air. Gel water (retained within the cement hydration products) and physically entrapped or adsorbed water are significant for the hydration process. For complete hydration, it's estimated that the space needed for the products of a cubic centimeter of cement doubles. Capillary pores constitute the unoccupied space within the hydrated cement paste, with their size largely influenced by the water-to-cement...
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The Wave Nature of Light02:12

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The nature of light has been a subject of inquiry since antiquity. In the seventeenth century, Isaac Newton performed experiments with lenses and prisms and was able to demonstrate that white light consists of the individual colors of the rainbow combined together. Newton explained his optics findings in terms of a "corpuscular" view of light, in which light was composed of streams of extremely tiny particles traveling at high speeds according to Newton's laws of motion.
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Limits to Natural Selection01:38

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Organisms that are well-adapted to their environment are more likely to survive and reproduce. However, natural selection does not lead to perfectly adapted organisms. Several factors constrain natural selection.
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Related Experiment Video

Updated: Jan 25, 2026

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
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Total Syntheses of Natural Polycyclic Sesterterpenoids With Anticancer Bioactivities.

Shaomin Fu1, Bo Liu1, Nanjing Li2

  • 1College of Chemistry, Sichuan University, Chengdu, Sichuan, China.

Chemistry, an Asian Journal
|January 24, 2026
PubMed
Summary

Natural products like sesterterpenoids offer potent anticancer agents. Modern synthetic chemistry now enables efficient access to these complex molecules for drug discovery and development.

Keywords:
anticancernatural productsesterterpenoidterpenoidtotal synthesis

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Area of Science:

  • Natural Products Chemistry
  • Organic Synthesis
  • Medicinal Chemistry

Background:

  • Cancer necessitates novel therapeutics, with natural products like terpenoids being a rich source.
  • Sesterterpenoids (C25) are a class of natural products with complex structures that have historically limited structure-activity relationship (SAR) studies.
  • Recent advances in synthetic methodologies have improved accessibility to sesterterpenoids and their analogs.

Purpose of the Study:

  • To review representative total syntheses of polycyclic sesterterpenoids (≥3 rings).
  • To highlight synthetic strategies for key sesterterpenoid subclasses: phorbaketals, ophiobolins, salmahyrtisol A, and scalaranes.
  • To underscore the role of synthetic advances in enabling biological studies and SAR optimization of anticancer sesterterpenoids.

Main Methods:

  • Survey of total synthesis methodologies for polycyclic sesterterpenoids.
  • Focus on specific synthetic strategies including gold-catalyzed spiroketalization, Nozaki-Hiyama-Kishi coupling, radical cascades, biomimetic approaches, reductive Heck cyclization, and intramolecular Diels-Alder reactions.
  • Analysis of how these syntheses provide access to diverse sesterterpenoid architectures.

Main Results:

  • Sesterterpenoids exhibit significant cytotoxicity against various cancer cell lines (nano- to micromolar range).
  • Diverse synthetic routes have been developed for phorbaketals, ophiobolins, salmahyrtisol A, and scalaranes, showcasing innovative chemical transformations.
  • These synthetic efforts provide scalable access to complex sesterterpenoids and their analogs.

Conclusions:

  • Modern synthetic chemistry is crucial for overcoming the structural complexity of sesterterpenoids.
  • Advances in synthesis facilitate biological evaluation and SAR-driven optimization of sesterterpenoids as anticancer agents.
  • This review highlights the potential of sesterterpenoids as a promising class of anticancer therapeutics.