Stereodivergent photooxidative synthesis of cyclocariols A, B, and E from ginsenoside Rg1
Jie Yuan1, Shaomin Fu1, Bo Liu1
1College of Chemistry, Sichuan University, Chengdu 610064, China. chembliu@scu.edu.cn.
Abstract:
We report a stereodivergent photooxidative synthesis of the 3,4-seco-dammarane triterpenoid cyclocariols A, B, and E from the commercially available ginsenoside Rg1. This study features a visible-light-induced β-fragmentation/elimination cascade reaction that constructs the seco-dammarane core, and a Schenck ene reaction that installs oxidative numbers at C24 and C25.
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