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Exploring Clinical Similarities and Distinctions Between Gastroparesis and Functional Dyspepsia: A Propensity-Matched
Sameer Rao1, Vraj Shah1, Rohan Karkra1
1Department of Medicine, Rutgers New Jersey Medical School, New Jersey, USA.
Neurogastroenterology and Motility
|January 24, 2026
Summary
Gastroparesis and functional dyspepsia present with different symptoms and treatments. Gastroparesis patients utilize more healthcare resources, indicating a need for tailored management strategies.
Area of Science:
- Gastroenterology
- Clinical Medicine
- Digestive Health
Background:
- Gastroparesis and functional dyspepsia share upper gastrointestinal symptoms but differ clinically.
- Distinguishing these conditions is crucial for effective patient management and healthcare resource allocation.
Purpose of the Study:
- To compare the clinical characteristics, treatment patterns, and healthcare utilization of gastroparesis and functional dyspepsia.
- To identify key distinctions between these two common gastrointestinal disorders.
Main Methods:
- Retrospective cohort study using the TriNetX database.
- Propensity score matching (1:1) to compare patients with gastroparesis and functional dyspepsia.
- Analysis of medication use, healthcare utilization, symptom burden, and coexisting disorders.
Main Results:
- Gastroparesis patients exhibited higher use of prokinetics and antiemetics, alongside increased endoscopy, emergency visits, and hospitalizations.
- Nausea, vomiting, and distension were more prevalent in gastroparesis, whereas epigastric pain characterized functional dyspepsia.
- The study included 1914 matched patients in each group.
Conclusions:
- Gastroparesis and functional dyspepsia demonstrate distinct symptom profiles and treatment approaches.
- Higher healthcare utilization in gastroparesis supports the need for mechanism-based, individualized treatment plans.
- These findings underscore the importance of differentiating gastroparesis from functional dyspepsia for optimal patient care.
Keywords:
disorders of gut brain interactionfunctional dyspepsiagastric emptyinggastroparesisprokineticsMore Related Videos
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