Related Experiment Video
Updated: Jan 26, 2026

Author Spotlight: Decoding Metastasis-to-Metastasis Seeding Using a New In Vivo Technique for Tracking Breast Cancer Spread
Published on: July 7, 2023
Atypical non-enhancing brain metastases from ALK-positive non-small cell lung carcinoma
Serdar Solmaz1, Cafer Ikbal Gulsever1
1Department of Neurosurgery, Hakkari State Hospital, Hakkari, Turkey.
Abstract:
Brain metastases are a frequent complication of advanced non-small cell lung carcinoma (NSCLC), particularly in anaplastic lymphoma kinase (ALK)-positive cases, which show a strong tendency for central nervous system spread. Typically, such metastases demonstrate contrast enhancement on magnetic resonance imaging (MRI) due to disruption of the blood-brain barrier. We report a 45-year-old man with ALK-positive NSCLC presenting with a right temporal swelling and multiple non-contrast-enhancing brain lesions detected before any treatment. The temporal mass was excised and confirmed as metastatic adenocarcinoma. The patient received whole-brain radiotherapy (30Gy in 10 fractions), cisplatin-pemetrexed chemotherapy, and sequential targeted therapy with alectinib and lorlatinib. During three years of follow-up, MRI showed complete resolution of all lesions, and the patient remained neurologically intact and systemically stable. This case underscores the rarity of non-enhancing brain metastases in ALK-positive NSCLC and highlights the importance of recognizing this atypical imaging presentation for timely diagnosis and management.
More Related Videos
08:47Improved Visualization of Lung Metastases at Single Cell Resolution in Mice by Combined In-situ Perfusion of Lung Tissue and X-Gal Staining of lacZ-Tagged Tumor Cells
Published on: August 21, 2012
07:53Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
Published on: March 17, 2020
Related Concept Videos
Antipsychotic Drugs: Typical and Atypical Agents
Chromatin Position Affects Gene Expression
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
Position-effect Variegation
Lung Capacity
Serial Position Effect
Self-Evaluation: Self-Enhancement and Self-Verification