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Nanoengineering-Based Strategies for Enhancing Dynamic Therapy.

Changsong Tian1,2, Yuxin Wang1,2,3, Zengzhen Chen1,2

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Nanoengineering sensitizers significantly boost dynamic therapy

Keywords:
TME remodelingdynamic therapyenhancementstructure optimization

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cancer Therapy

Background:

  • Dynamic therapy shows promise in biomedicine due to high efficiency and low toxicity.
  • Nanoengineering offers a way to improve antitumor efficacy in dynamic therapy.

Purpose of the Study:

  • To comprehensively review nanoengineering strategies for enhancing dynamic therapy.
  • To discuss challenges and future directions in dynamic sensitizer development.

Main Methods:

  • Review of nanoengineering strategies for different dynamic sensitizer types.
  • Analysis of methods to improve tumor targeting, microenvironment modulation, and ROS effects.
  • Exploration of AI-enabled strategies for sensitizer preparation.

Main Results:

  • Nanoengineering can enhance dynamic therapy by optimizing sensitizer performance and addressing cross-cutting concerns.
  • Strategies include improving tumor accumulation, modulating the tumor microenvironment, and optimizing ROS-mediated effects.
  • AI presents emerging opportunities for next-generation sensitizer development.

Conclusions:

  • Nanoengineering is crucial for advancing dynamic therapy.
  • Addressing challenges in mechanism understanding and manufacturing is essential.
  • Future research should focus on AI-driven approaches for novel sensitizer design.