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Updated: Jan 27, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Discovery of 7-(Pyridin-3-yl)thieno[3,2-b]pyridine-5-carboxamides as Negative Allosteric Modulators of Metabotropic

Scott H Henderson1,2, Anna E Ringuette1,2, David L Whomble1,2,3

  • 1Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.

ACS Chemical Neuroscience
|January 26, 2026
PubMed

Keywords:
Alzheimer’sVU6035386leveodopa-induced dyskinesiamGlu5metabotropic glutamate receptor subtype 5negative allosteric modulatorpainstructure−activity relationship

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