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The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
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The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
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Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Exploring Pembrolizumab-Induced IM3OS in a Patient With Bladder Cancer.

Ching-Cheng Chan1, Ming-Jen Lee2, Jian Su3

  • 1Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan.

Pharmacology Research & Perspectives
|January 26, 2026
PubMed
Summary
This summary is machine-generated.

Pembrolizumab, an immune checkpoint inhibitor, can cause rare but severe neurological and cardiac side effects in urothelial cancer patients. Early detection of conditions like myocarditis-myositis-myasthenia gravis overlap syndrome is crucial for prompt intervention.

Area of Science:

  • Oncology
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  • Neurology

Background:

  • Immune checkpoint inhibitors (ICIs) like pembrolizumab are vital in treating metastatic urothelial cancer.
  • Understanding the adverse effects of widespread ICI use is critical.

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