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Characterization of a Bioprinted Anticancer Cell Therapy System Generated with Continuous Liquid Interface

Lauren Kass1, Ike Keku1, Yu Zhang1

  • 1Division of Pharmacoengineering and Molecular Pharmaceutics UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill 4212 Marsico Hall, 125 Mason Farm Road, Chapel Hill, NC 27599, USA.

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Summary

Continuous liquid interface production (CLIP) enables rapid 3D bioprinting of cell therapies. CLIP-bioprinted cells show enhanced survival and efficacy against glioblastoma in vivo, improving outcomes.

Keywords:
3D bioprintingcell therapiescontinuous liquid interface productionsglioblastomas

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Cancer Therapy

Background:

  • Anticancer cell therapies show promise but face delivery challenges.
  • 3D bioprinting (3DBP) offers a solution for creating cell delivery devices.
  • Continuous liquid interface production (CLIP) is a 3DBP technology with potential for cell therapy.

Purpose of the Study:

  • To investigate the feasibility of CLIP for 3D bioprinting cell-laden scaffolds.
  • To evaluate the efficacy of CLIP-bioprinted cell therapies in vitro and in vivo.
  • To establish CLIP as a platform for advanced cell therapy delivery devices.

Main Methods:

  • Utilized CLIP 3D bioprinting with a gelatin methacrylate resin.
  • Incorporated drug-secreting fibroblasts as a model anticancer therapy.
  • Assessed cell viability, in vitro efficacy, and in vivo survival in a glioblastoma mouse model.

Main Results:

  • CLIP enabled rapid and consistent production of cell-laden scaffolds.
  • Printed cells maintained viability and anticancer efficacy post-printing.
  • Bioprinted cells exhibited improved in vivo survival compared to direct injection, correlating with better outcomes.

Conclusions:

  • CLIP is a viable technology for 3D bioprinting of cell therapy delivery devices.
  • CLIP-bioprinted cell therapies demonstrate enhanced therapeutic potential against glioblastoma.
  • This study provides a foundation for developing sophisticated cell therapy delivery systems using CLIP.