Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 13, 2026

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer
07:05

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Published on: September 22, 2015

High-Resolution 3D Bioprinted Hydrogel Scaffolds Enable Sustained Intraperitoneal Cell Delivery.

Yu Zhang1, Lauren E Carlberg1, Cali N Colliver2

  • 1Division of Pharmacoengineering and Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Molecules (Basel, Switzerland)
|June 12, 2026
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Latent Catalysis as a Platform for Accessing Diverse Material Properties in Vat Photopolymerization 3D Printing.

Angewandte Chemie (International ed. in English)·2026
Same author

A novel ex vivo platform for functional evaluation of treatment responses in metastatic ovarian cancer.

NPJ precision oncology·2026
Same author

Injectable thermoresponsive hydrogel scaffold for enhanced delivery of next-generation induced neural stem cells for treatment of glioblastoma.

Drug delivery and translational research·2026
Same author

Injectable thermo-responsive hydrogel scaffold for enhanced delivery of second-generation induced neural stem cells for treatment of glioblastoma.

Research square·2026
Same author

Characterization of a Bioprinted Anticancer Cell Therapy System Generated with Continuous Liquid Interface Production.

Advanced nanobiomed research·2026
Same author

Combinatorial treatment of glioblastoma with temozolomide (TMZ) plus 5-ethynyl-2'-deoxyuridine (EdU).

Proceedings of the National Academy of Sciences of the United States of America·2025
Same journal

RETRACTED: Atta et al. Effect of Montmorillonite Nanogel Composite Fillers on the Protection Performance of Epoxy Coatings on Steel Pipelines. <i>Molecules</i> 2017, <i>22</i>, 905.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Chen et al. Chemical Composition of <i>Litsea pungens</i> Essential Oil and Its Potential Antioxidant and Antimicrobial Activities. <i>Molecules</i> 2023, <i>28</i>, 6835.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Ruan et al. Comparison of Extraction, Isolation, Purification, Structural Characterization and Immunomodulatory Activity of Polysaccharides from Two Species of <i>Cistanche</i>. <i>Molecules</i> 2025, <i>30</i>, 4754.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Li et al. Gastrodin Ameliorates Cognitive Dysfunction in Vascular Dementia Rats by Suppressing Ferroptosis via the Regulation of the Nrf2/Keap1-GPx4 Signaling Pathway. <i>Molecules</i> 2022, <i>27</i>, 6311.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Zueva et al. Steady-State Kinetics of Enzyme-Catalyzed Hydrolysis of Echothiophate, a P-S Bonded Organophosphorus as Monitored by Spectrofluorimetry. <i>Molecules</i> 2020, <i>25</i>, 1371.

Molecules (Basel, Switzerland)·2026
Same journal

1,4-Diazatriphenylene and Its Hetero-Fused Analogs: Synthesis and Applications.

Molecules (Basel, Switzerland)·2026
See all related articles
This summary is machine-generated.

This study developed a 3D bioprinted hydrogel scaffold for intraperitoneal (I.P.) cell therapy, significantly extending cell persistence in vivo. The innovative biomaterial platform enhances therapeutic durability for regional peritoneal diseases.

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • 3D Bioprinting

Background:

  • Intraperitoneal (I.P.) cell therapy shows promise for peritoneal diseases but suffers from rapid cell loss.
  • A need exists for implantable biomaterials that integrate mechanically and sustain cell viability within the I.P. cavity.

Purpose of the Study:

  • To engineer transplantable, cell-laden hydrogel scaffolds using Continuous Liquid Interface Production (CLIP) 3D bioprinting for I.P. implantation.
  • To optimize bioresin formulation for mechanical properties, printability, and biodegradation suitable for the dynamic I.P. environment.

Main Methods:

  • Developed a CLIP-based 3D bioprinting strategy for cell-laden hydrogel scaffolds.
  • Systematically designed bioresins, identifying a GelMA-PEGDA formulation with specific mechanical and degradation profiles.
Keywords:
3D bioprintingContinuous Liquid Interface Printing (CLIP)cell deliveryhydrogel scaffoldsintraperitoneal implant

More Related Videos

Bioprintable Alginate/Gelatin Hydrogel 3D In Vitro Model Systems Induce Cell Spheroid Formation
16:20

Bioprintable Alginate/Gelatin Hydrogel 3D In Vitro Model Systems Induce Cell Spheroid Formation

Published on: July 2, 2018

Related Experiment Videos

Last Updated: Jun 13, 2026

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer
07:05

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Published on: September 22, 2015

Bioprintable Alginate/Gelatin Hydrogel 3D In Vitro Model Systems Induce Cell Spheroid Formation
16:20

Bioprintable Alginate/Gelatin Hydrogel 3D In Vitro Model Systems Induce Cell Spheroid Formation

Published on: July 2, 2018

  • Evaluated scaffold performance in vitro for cell viability and proliferation.
  • Assessed in vivo cellular persistence after I.P. implantation in a mouse model.

    • Main Results:

    • Identified a GelMA-PEGDA hydrogel with optimal printability, tissue-matched mechanics (10-15 kPa), and controlled biodegradation.
    • Demonstrated sustained cell viability and proliferation (>30 days in vitro).
    • Achieved a ~10-fold increase in cellular persistence in vivo compared to direct injection (30 days vs. 3 days for 50% signal decay).
    • Showed retention of multiple cell types, including stem cells.

    Conclusions:

    • CLIP-based 3D bioprinting is a scalable strategy for creating I.P. implantable cell therapeutics.
    • Key material and architectural parameters were defined for successful I.P. cell delivery.
    • The developed platform significantly enhances therapeutic durability for regional peritoneal diseases.