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Iris RESTful Server and IrisTileSource: An Iris implementation for existing OpenSeaDragon viewers.

Ryan Erik Landvater1, Navin Kathawa1, Mustafa Yousif1

  • 1University of Michigan Medical School, Department of Pathology, 2800 Plymouth Road, Ann Arbor, MI 48109-2800, USA.

Journal of Pathology Informatics
|January 26, 2026
PubMed
Summary
This summary is machine-generated.

The Iris RESTful Server improves whole-slide image (WSI) viewing by enabling native streaming of Iris File Extension (IFE) files. This high-performance solution integrates with OpenSeaDragon, simplifying WSI workflows for pathologists and administrators.

Keywords:
Digital pathologyIrisIris File ExtensionOpenSeaDragonRESTfulTileSourceWhole-slide image

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Area of Science:

  • Digital Pathology
  • Medical Imaging Informatics
  • Computer Science

Background:

  • Whole-slide imaging (WSI) file formats like Iris File Extension (IFE) require efficient streaming for pathology applications.
  • Traditional HTTP servers struggle with natively streaming subregions of high-resolution WSI files.
  • Current WSI viewers often convert files to Deep Zoom Images (DZI) for compatibility, limiting functionality.

Purpose of the Study:

  • To develop a low-overhead, high-performance HTTP server for native IFE file streaming.
  • To create a RESTful API compatible with DICOMweb WADO-RS for seamless integration.
  • To enhance WSI viewer systems with improved rendering and management capabilities.

Main Methods:

  • Developed the Iris RESTful Server using C++, Boost Beast HTTP, and Asio networking libraries.
  • Implemented native compatibility with the DICOMweb WADO-RS API.
  • Created and merged a new OpenSeaDragon TileSource compatible with the Iris RESTful API.

Main Results:

  • The Iris RESTful Server demonstrates high performance, handling an average of 3883 requests/second with a median latency of 21ms on minimal hardware.
  • A new OpenSeaDragon TileSource enables direct integration, replacing DZI conversions.
  • The server functions as a secure, cross-origin resource sharing microservice.

Conclusions:

  • The Iris RESTful Server provides a secure, high-performance solution for streaming WSI files, enhancing digital pathology workflows.
  • This architecture simplifies WSI management and improves the user experience for pathologists.
  • The open-source availability accelerates the development and adoption of advanced WSI web viewers.