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Updated: Jan 27, 2026

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies
05:42

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies

Published on: August 11, 2023

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Matrix metalloproteinases-3 gene-promoter polymorphism as a risk factor in oral submucous fibrosis: A systematic

Dipak D Ghatage1, Akshay A Dhobley1, Devendra H Palve1

  • 1Oral Pathology and Microbiology Department, Government Dental College And Hospital, Nagpur, Maharashtra, India.

Journal of Oral and Maxillofacial Pathology : JOMFP
|January 26, 2026
PubMed

Insights

The MMP3 -1171 5A/6A promoter polymorphism significantly increases oral submucous fibrosis risk by nearly threefold. Homozygous genotypes showed no significant association with this potentially malignant disorder.

Area of Science:

  • Genetics
  • Oncology
  • Biochemistry

Background:

  • Oral submucous fibrosis (OSF) is a progressive, potentially malignant oral disorder.
  • Matrix metalloproteinase-3 (MMP3) plays a role in extracellular matrix remodeling.
  • Genetic variations in MMP3 may influence susceptibility to OSF.

Purpose of the Study:

  • To systematically review and meta-analyze the association between MMP3 expression, promoter polymorphism, and OSF risk.
  • To evaluate the impact of MMP3 gene variations on OSF susceptibility.

Main Methods:

  • Systematic literature search of PubMed, Cochrane, Google Scholar, and ScienceDirect (2000-2023).
  • Meta-analysis of four eligible studies using RevMan 5.4, calculating pooled odds ratios (ORs) and 95% confidence intervals (CIs).
  • Assessment of heterogeneity (I² statistics) and publication bias (funnel plot, Egger's test).

Main Results:

  • The heterozygous MMP3 -1171 5A/6A promoter polymorphism was significantly associated with increased OSF susceptibility (OR = 2.75, 95% CI 1.63-4.64, P = 0.0002).
  • No significant association was found for homozygous 5A/5A (OR = 2.34) or 6A/6A (OR = 1.23) genotypes.
  • Egger's test indicated no publication bias; studies showed acceptable quality.

Conclusions:

  • The MMP3 -1171 5A/6A promoter polymorphism is linked to a nearly threefold increased risk of OSF.
  • MMP3 promoter variations may contribute to OSF pathogenesis.
  • Further large-scale studies are needed to confirm these findings and explore diagnostic/preventive potential.
Keywords:
Gene polymorphismMMP3matrix metalloproteinasesoral submucous fibrosis

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