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Assessing Generative AI Chatbots for Alcohol Misuse Support: A Longitudinal Simulation Study
Lori Uscher-Pines1, Jessica L Sousa2, Pushpa Raja3
1RAND Corporation, Arlington, Virginia.
NEJM AI
|January 26, 2026
Summary
Large language model (LLM) chatbots show promise for behavioral health support, particularly in empathy. However, their advice on alcohol misuse requires improvement in information quality and accuracy.
Area of Science:
- Digital Health
- Artificial Intelligence in Healthcare
- Mental Health Technology
Background:
- Large language model (LLM) chatbots are increasingly utilized for behavioral health support.
- Rigorous evaluations of their advice on alcohol misuse are limited.
Purpose of the Study:
- To evaluate the performance of publicly available chatbots in responding to alcohol misuse scenarios.
- To assess chatbot interactions across domains including empathy, information quality, and usefulness.
Main Methods:
- Seven chatbots (general and behavioral health-focused) were tested using simulated longitudinal interactions over seven days.
- Clinicians rated transcripts based on empathy, information quality, usefulness, responsiveness, and scope awareness.
- Secondary assessments included stigmatizing language and validation versus challenging the user.
Main Results:
- Empathy was the highest-rated domain (mean score 4.6/5), while quality of information was the lowest (mean 2.7/5).
- Performance varied significantly across chatbots, with no difference between general and behavioral health types.
- All chatbots provided some inappropriate, overstated, or inaccurate guidance, despite avoiding stigmatizing language.
Conclusions:
- Chatbots demonstrate strengths in empathy but require significant improvement in the quality and accuracy of information provided for alcohol misuse support.
- Users and clinicians should be aware of current chatbot limitations in this domain.
- Further development is needed to enhance the reliability of AI-driven behavioral health tools.
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