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Transforming Coagulation Testing: The Role of Biosensors in Prothrombin Time (PT) Measurement
Induni Nayodhara Weerarathna1, Praveen Kumar2, Siah Kundy3
1Department of Biomedical Sciences, Datta Meghe Institute of Higher Education and Research Deemed to be university, Wardha, Maharashtra-442107, India.
ACS Omega
|January 26, 2026
Summary
Biosensors offer a revolutionary approach to prothrombin time (PT) testing, enabling faster, more accurate, and accessible blood coagulation monitoring. These advancements promise to enhance patient care through point-of-care and home-based testing solutions.
Area of Science:
- Biomedical Engineering
- Clinical Diagnostics
- Nanotechnology
Background:
- Prothrombin time (PT) is crucial for diagnosing clotting disorders, managing anticoagulant therapy, and assessing liver function.
- Traditional PT testing relies on centralized labs, posing challenges in cost, time, and accessibility for many patients.
- Biosensor technology presents a transformative solution to overcome the limitations of conventional PT testing methods.
Purpose of the Study:
- To explore the advancements in biosensor technology for prothrombin time (PT) monitoring.
- To discuss the fundamental principles, current developments, and potential applications of PT biosensors.
- To highlight the significance of biosensors in improving PT assessment and clinical outcomes.
Main Methods:
- Integration of microfluidics, nanotechnology, and bio-MEMS for precise coagulation monitoring.
- Development of portable biosensor devices compatible with digital health platforms for point-of-care (PoC) and home use.
- Focus on strategies to enhance sensitivity, selectivity, and cost-effectiveness in PT biosensor design.
Main Results:
- Biosensors facilitate rapid, accurate, and minimally invasive coagulation monitoring.
- Increased utility in point-of-care and home-based settings due to device portability and digital integration.
- Potential for personalized healthcare through accessible and individualized coagulation monitoring.
Conclusions:
- Biosensors are pivotal in advancing PT assessment, offering improved clinical results.
- These technologies can revolutionize diagnostics by providing efficient and affordable coagulation monitoring solutions.
- Continued research and interdisciplinary collaboration are essential for realizing the full potential of PT biosensors in diverse healthcare settings.
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