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Updated: Jan 28, 2026
03:36
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
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Increased Risk of Second Squamous Cell Carcinomas Following Cervical Cancer: A Nationwide Danish Case-Control Study
Sara Bønløkke1,2, Jan Blaakær3,4, Torben Steiniche1
1Department of Clinical Medicine, Aarhus University, Aarhus N, Denmark.
Cancer Medicine
|January 27, 2026
Summary
Cervical cancer (CC) survivors show a reduced overall risk of second cancers, but an increased risk of lung cancer and second squamous cell carcinomas (SCCs), especially lung SCC. This necessitates tailored long-term monitoring for these survivors.
Area of Science:
- Oncology
- Cancer Epidemiology
- Public Health
Background:
- Investigating the long-term health outcomes of cervical cancer (CC) survivors is crucial for understanding cancer survivorship.
- Previous studies suggest varying risks of secondary malignancies post-CC diagnosis.
Purpose of the Study:
- To determine the risk of developing second primary cancers among women previously diagnosed with cervical cancer.
- To compare this risk against cancer-free women in a nationwide cohort.
Main Methods:
- A nationwide case-control study using the Danish Cancer Registry (DCR) and Danish Pathology Register.
- Included women aged 18+ diagnosed with CC between 1987-2012, matched 1:5 with cancer-free controls.
- Estimated adjusted sub-hazard ratios (aSHR) for subsequent primary cancers.
Main Results:
- CC survivors (n=10,728) had a significantly lower overall risk of second primary cancers (aSHR: 0.87).
- Reduced risks observed for colorectal, breast cancers, and malignant melanoma; increased risk for lung cancer (aSHR: 1.33).
- Squamous cell carcinoma of the cervix (SCC-C) survivors showed increased risk for second SCCs at both HPV-related and non-HPV sites, notably lung SCC (aSHR: 2.88).
Conclusions:
- Cervical cancer survivors experience a lower overall risk of subsequent cancers but face elevated risks for specific types, including lung cancer and second SCCs.
- The heightened incidence of lung SCC among SCC-C survivors underscores the need for specialized, long-term surveillance strategies.
- Findings emphasize the importance of personalized follow-up care for CC survivors to detect secondary malignancies early.
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