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Updated: Jan 28, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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A multifunctional nanocatalytic ferroptosis amplifier based on glutathione scavenging and lipid peroxidation

Yafei Lin1, Xue Han1, Lei Wang1

  • 1Department of Ultrasound, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, P. R. China. ultra_gaiyonghao@163.com.

Journal of Materials Chemistry. B
|January 27, 2026
PubMed

Insights

This study introduces a novel nanodrug, IrOₓ@HMME-HSA, to enhance ferroptosis cancer therapy. It combines photothermal and sonodynamic therapy to overcome tumor resistance and promote cell death.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cancer Therapy

Background:

  • Ferroptosis is a cell death pathway involving lipid peroxidation and GPX4 activity.
  • Photothermal therapy can induce ferroptosis but faces challenges with thermotolerance.
  • Sonodynamic therapy (SDT) generates reactive oxygen species (ROS) to combat thermotolerance.

Purpose of the Study:

  • To develop a novel nanodrug for enhanced ferroptosis-inducing cancer therapy.
  • To overcome tumor microenvironment challenges like hypoxia and antioxidant defenses.
  • To address laser-responsive heat tolerance issues in photothermal therapy.

Main Methods:

  • Construction of the IrOₓ@HMME-HSA nanodrug.
  • Utilizing iridium oxide (IrOₓ) for photothermal effects and System Xc⁻ regulation.
  • Employing hematoporphyrin monomethyl ether (HMME) for SDT-induced ROS and lipid peroxidation.

Main Results:

  • The nanodrug effectively regulates the System Xc⁻-glutathione (GSH)-GPX4 pathway.
  • SDT component alleviates thermotolerance and promotes lipid peroxidation.
  • Demonstrated a novel strategy for cancer therapy via amplified GSH depletion and ferroptosis.

Conclusions:

  • IrOₓ@HMME-HSA offers a promising strategy for ferroptosis-enhanced cancer therapy.
  • The study provides a foundation for iridium-based nanodrugs in cancer treatment.
  • Addresses key challenges in tumor therapy including resistance and microenvironment factors.

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