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Hydrogel as a Platform for Point-of-Care Calcium Determination in Blood
Tatiana N Tikhonova1, Anastasia V Barkovaya1, Yuri M Efremov2
1Department of Physics, M.V. Lomonosov Moscow State University, Leninskie Gory 1/2, 119991 Moscow, Russia.
Gels (Basel, Switzerland)
|January 27, 2026
Summary
This study introduces a fast, point-of-care method using gelatin hydrogel to measure blood calcium levels. The assay simplifies sample preparation for monitoring calcium metabolism disorders.
Area of Science:
- Biomedical Engineering
- Analytical Chemistry
- Clinical Diagnostics
Background:
- Calcium is vital for physiological processes, and blood calcium levels are key diagnostic indicators.
- Accurate and rapid calcium determination is crucial for diagnosing various diseases.
Purpose of the Study:
- To develop a novel, rapid point-of-care method for determining total calcium content in patient blood.
- To evaluate hydrogel materials as a platform for blood calcium analysis.
Main Methods:
- A gelatin hydrogel modified with Arsenazo III optical sensor was used for blood separation and calcium detection.
- Comparative analysis of various hydrogel materials (polyacrylamide, PVA, Fmoc-FF, carbomer, carbopol, gelatin) was conducted.
- Photometric determination of calcium concentration based on spectral changes upon ion binding.
Main Results:
- Gelatin hydrogel was identified as the only suitable material among those tested for blood calcium determination.
- The method successfully enabled photometric determination of calcium concentrations in blood plasma.
- The assay demonstrated speed and simplicity in sample preparation.
Conclusions:
- The developed rapid assay allows for effective monitoring of calcium metabolism disorders.
- The gelatin hydrogel-based method shows potential for integration into clinical practice due to its efficiency.
- This point-of-care approach offers a simplified alternative for blood calcium analysis.
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