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Updated: Jan 28, 2026

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Published on: December 9, 2022

[Isolated cecal necrosis].

S E Krylov¹, E A Cheburkova¹, N K Razumovsky¹

¹Nizhny Novgorod City Clinical Hospital No. 40, Nizhny Novgorod, Russia.

|January 27, 2026

Summary

This summary is machine-generated.

Isolated cecal necrosis is a rare condition that often mimics appendicitis. Diagnosis is challenging due to a lack of specific indicators, requiring intraoperative confirmation.

Keywords:

acute appendicitis cecum isolated cecal necrosis

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Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

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Area of Science:

Gastroenterology
Surgical Pathology

Background:

Isolated cecal necrosis is a rare condition with an unclear cause.
It frequently presents symptoms similar to acute appendicitis.
Diagnostic challenges arise from the absence of specific clinical, laboratory, and imaging findings.

Purpose of the Study:

To highlight the diagnostic difficulties of isolated cecal necrosis.
To present cases of intraoperatively diagnosed isolated cecal necrosis.

Main Methods:

Retrospective review of three cases diagnosed intraoperatively.
Analysis of clinical presentation, diagnostic workup, and surgical findings.

Main Results:

Three cases of isolated cecal necrosis were identified and diagnosed intraoperatively.
The condition mimicked acute appendicitis in all presented cases.

Conclusions:

Intraoperative diagnosis is crucial for isolated cecal necrosis.
Further research is needed to understand the etiology and improve diagnostic accuracy.