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Bacterial Nanocellulose Functionalized with Graphite and Niobium Pentoxide: Limited Antimicrobial Effects and
Juliana Silva Ribeiro de Andrade1, Adriana Poli Castilho Dugaich1, Andressa da Silva Barboza1
1Department of Dentistry, Federal University of Santa Catarina (UFSC), Florianópolis 88040-535, SC, Brazil.
Membranes
|January 27, 2026
Summary
Bacterial nanocellulose (BNC) modified with functionalized graphite (f-Gr) shows promise as an antimicrobial wound dressing, effectively reducing bacterial growth. Niobium pentoxide (Nb2O5) did not significantly enhance these effects.
Area of Science:
- Biomaterials Engineering
- Nanotechnology
- Infectious Disease Research
Background:
- Chronic wounds present challenges due to persistent inflammation and high microbial load.
- Bacterial nanocellulose (BNC) offers biocompatibility but lacks inherent antimicrobial properties.
- Novel dressings are needed to combat wound infections while maintaining biocompatibility.
Purpose of the Study:
- To engineer and evaluate BNC membranes functionalized with functionalized graphite (f-Gr) and/or niobium pentoxide (Nb2O5) for antimicrobial wound dressing applications.
- To assess the physicochemical properties and antimicrobial efficacy of the modified BNC materials.
- To determine the biocompatibility of the developed BNC-based composites.
Main Methods:
- BNC membranes were post-functionalized with f-Gr and/or Nb2O5.
- Physicochemical characterization using Raman, FTIR-ATR, XRD, and SEM.
- Microbiological assays evaluated bacterial proliferation against Staphylococcus aureus.
- Cytotoxicity assays assessed material biocompatibility.
Main Results:
- Physicochemical analyses confirmed the incorporation of f-Gr and Nb2O5 into the BNC matrix.
- BNC/f-Gr demonstrated moderate, contact-dependent antimicrobial activity, particularly against Staphylococcus aureus.
- Nb2O5 alone did not significantly improve antimicrobial performance.
- Cytotoxicity assays showed good biocompatibility for BNC, BNC/f-Gr, and BNC/Nb2O5.
Conclusions:
- BNC functionalized with f-Gr is a promising candidate for antimicrobial wound dressings.
- Nb2O5 did not enhance antimicrobial activity under tested conditions and requires further optimization.
- The developed BNC/f-Gr material offers a potential solution for managing chronic wound infections.
Keywords:
antimicrobialbacterial nanocellulosebioactive compositesbiomaterialschronic woundscytocompatibilityfunctionalized graphiteniobium pentoxidespectroscopic characterizationMore Related Videos
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