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Updated: Jan 28, 2026
08:55
Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles PPAs and Related Biomaterials
Published on: June 25, 2018
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Functional Peptide-Based Biomaterials for Pharmaceutical Application: Sequences, Mechanisms, and Optimization
Dedong Yu1, Nari Han1, Hyejeong Son1
1College of Pharmacy, Chonnam National University, Gwangju 61186, Republic of Korea.
Journal of Functional Biomaterials
|January 27, 2026
Summary
Peptide biomaterials offer precise, biocompatible drug delivery solutions. Advances in design and AI integration accelerate their clinical translation for enhanced pharmaceutical applications.
Area of Science:
- Biomaterials Science
- Pharmaceutical Sciences
- Drug Delivery
Background:
- Peptide-based biomaterials are promising for drug delivery due to biocompatibility and sequence tunability.
- A comprehensive overview of their categories, mechanisms, and optimization is needed for clinical translation.
Purpose of the Study:
- To systematically review advances in peptide-based biomaterials for drug delivery.
- To cover categories, mechanisms, and optimization strategies for clinical translation.
Main Methods:
- Systematic collation of advances in peptide-based biomaterials.
- Categorization into peptide excipients, self-assembling peptides, and peptide linkers.
- Dissection of sequence-based optimization strategies, including AI assistance.
Main Results:
- Cell-penetrating peptides facilitate intracellular delivery.
- Self-assembling peptides form nanostructures for controlled release.
- Peptide linkers enable site-specific drug release, with optimization enhancing stability and targeting.
Conclusions:
- Peptide-based biomaterials provide precise, biocompatible, and tunable drug delivery solutions.
- AI-driven design and multi-functional modifications will accelerate clinical translation.
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