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Updated: Jan 28, 2026
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Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
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Advanced Biomaterials for Craniofacial Tissue Regeneration: From Fundamental Mechanism to Translational
Żaneta Anna Mierzejewska1, Valentina Veselinović2, Nataša Trtić2
1Institute of Biomedical Engineering, Faculty of Mechanical Department, Bialystok University of Technology, Wiejska 45C, 15-351 Bialystok, Poland.
Journal of Functional Biomaterials
|January 27, 2026
Summary
Maxillofacial surgery is advancing with new biomaterials and regenerative medicine, focusing on patient-specific tissue repair. Innovations in stem cell therapy and biofabrication are enabling biologically integrated craniofacial reconstruction.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Maxillofacial Surgery
Background:
- Maxillofacial reconstruction traditionally relies on grafts and implants.
- Emerging regenerative strategies offer potential for improved functional and aesthetic outcomes.
Purpose of the Study:
- To review current and emerging strategies for craniofacial bone and soft-tissue regeneration.
- To highlight advancements in biomaterials, immunomodulation, stem cell therapy, and biofabrication.
Main Methods:
- Comprehensive literature review of recent advances.
- Focus on bioactive ceramics, biodegradable polymers, hybrid composites, and smart materials.
- Examination of translational technologies like extracellular vesicles, decellularized matrices, organoids, and 3D bioprinting.
Main Results:
- Biomaterials and regenerative approaches are transforming maxillofacial surgery.
- Key translational technologies show promise but face challenges like bioink standardization and perfusion.
Conclusions:
- Maxillofacial surgery is shifting towards personalized, biologically active tissue regeneration.
- Clinical scalability of advanced regenerative solutions is a key future direction.
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