Related Experiment Video
Updated: Jan 29, 2026

Sex Differences in Mouse Hippocampal Astrocytes after In-Vitro Ischemia
Published on: October 25, 2016
Sex differences in wheelchair marathon performance
Matthew M Hanks, Joshua M Leonardis1, Adam W Bleakney
1School of Health and Rehabilitation Sciences, College of Medicine, The Ohio State University, Columbus, OH, USA.
Objective:
To evaluate the historical trends of sex differences in athletic performance and participation among male and female wheelchair marathon athletes.
Design:
This retrospective, observational study utilized secondary, publicly available data of the Boston, Chicago, and New York City marathons within the Wheelchair Division from 1984 to 2023. Athletic performance and participation were evaluated across all marathon events and over time using univariate analysis of variance and Pearson correlations.
Results:
Sex differences in athletic performance were observed with males outperforming females in all marathon events over time (p < 0.001). The sex difference among first place finishers was 20% and increased to 33% for tenth place finishers. Though sex differences decreased over time (p < 0.001), large sex differences in performance remain. Female athlete participation in wheelchair marathon events significantly increased over time (p < 0.001) and the ratio of male athletes to female athletes in these events significantly decreased over time (p < 0.001). Overall participation and male athlete participation also generally increased over time.
Conclusion:
Significant sex differences were observed in wheelchair marathon performance and participation. These findings highlight the importance of sex as a key biological variable related to human health and performance, especially among wheelchair athletes.
Related Concept Videos
Sex-linked Disorders
Electric Potential and Potential Difference
When a test charge moves from the initial to the final position, the electric potential difference between those positions is defined as the ratio of the change in the potential energy to the charge on the...
Difference from Background: Limit of Detection
The LOD indicates the presence or absence...
Identifying Statistically Significant Differences: The F-Test
Sum and Difference OpAmps
A summing amplifier, or an adder, utilizes an op-amp to merge multiple input signals into a single output signal. When audio signals are introduced into its input channels, the input resistors initiate currents that traverse feedback resistors, resulting in an output voltage. Applying Kirchhoff's current...
Difference Equation Solution using z-Transform
The z-transform facilitates handling delayed signals by shifting the signal in the z-domain, which corresponds to delaying the signal in the time domain, and advancing signals by similarly shifting in the...

