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Published on: October 11, 2013
Dimerized Power: The Antimicrobial and Antiviral Promise of Biflavonoids
Hatice Duman1, Sercan Karav1, Anita Šalić2
1Department of Molecular Biology and Genetics, Çanakkale Onsekiz Mart University, Çanakkale 17100, Türkiye.
Abstract:
Biflavonoids, a unique class of naturally occurring polyphenolic compounds formed by the dimerization of flavonoid units, have attracted increasing scientific interest due to their diverse biological activities and structural complexity. This review provides a comprehensive overview of their natural occurrence, synthetic strategies, and antimicrobial properties, with a particular focus on their antibacterial, antifungal, and antiviral activities. Comparative analyses indicate that biflavonoids often display enhanced or distinct biological effects compared to their monomeric flavonoid counterparts, suggesting that dimerization plays a crucial role in modulating bioactivity. Overall, biflavonoids represent an underexplored yet highly promising group of natural compounds with significant potential for the development of novel antimicrobial and antiviral agents. Continued interdisciplinary research integrating natural product chemistry, pharmacology, and computational modeling will be essential to fully realize their therapeutic potential.
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