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Maresins
Fernanda Berrocal-Navarrete1,2, Paz Marín-Sanhueza1,3, Ramón Norambuena-González1,2
1Laboratory of Pharmacology and Physiology, Faculty of Health Sciences, University of Talca, Av. Lircay s/n, Talca 3460000, Chile.
Biomolecules
|January 28, 2026
Summary
Maresins (MaRs), derived from omega-3 fatty acids, actively resolve inflammation and promote tissue repair. Further research is needed to fully utilize MaRs for treating inflammatory diseases.
Area of Science:
- Lipid mediators
- Inflammation resolution
- Biochemistry
Background:
- Polyunsaturated fatty acids (PUFAs), like docosahexaenoic acid (DHA), are precursors to specialized pro-resolving mediators (SPMs).
- Maresins (MaRs) are SPMs with significant immunomodulatory and tissue-regenerative properties, attracting research interest.
Purpose of the Study:
- To synthesize current knowledge on maresin (MaR) biosynthesis, structural diversity, and biological functions, focusing on MaR1.
- To highlight the roles of MaRs in modulating inflammation, enhancing phagocytosis, and restoring tissue homeostasis.
Main Methods:
- Review of enzymatic pathways for generating MaR1, MaR2, MaRs conjugates in tissue regeneration (MCTRs), and maresin-like lipid mediators (MaR-Ls).
- Analysis of preclinical evidence from in vitro and in vivo models across various pathological contexts.
Main Results:
- MaRs demonstrate protective effects in neuroinflammation, liver injury, cardiovascular dysfunction, pulmonary diseases, and metabolic disorders.
- Evidence supports the therapeutic potential of MaRs in diverse inflammatory conditions.
Conclusions:
- Significant gaps exist in understanding MaRs biosynthesis, receptor specificity, and translational applications.
- Further mechanistic and clinical research is crucial to develop MaRs for next-generation therapeutics in inflammation-driven diseases.
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