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Updated: Jan 29, 2026

Author Spotlight: Decoding Corneal Neovascularization with Alkali Burn Model for Future Therapeutic Strategies
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Corneal Neovascularization: Pathogenesis, Current Insights and Future Strategies.

Evita Muller1, Leo Feinberg1,2, Małgorzata Woronkowicz3,4

  • 1West of England Eye Unit, Royal Devon University Healthcare NHS Foundation Trust, Exeter EX2 5DW, UK.

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|January 28, 2026
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Summary

Corneal neovascularization (CoNV) is a vision-impairing condition. This review explores therapeutic targets and strategies, including gene therapy and combination treatments, for managing CoNV and improving visual outcomes.

Keywords:
CRISPRCoNVVEGFangiogenesisanti-VEGFantiangiogenesiscorneacorneal neovascularizationgene-editingocular nanosystemsvascular endothelial growth factor

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Area of Science:

  • Ophthalmology
  • Angiogenesis Research
  • Corneal Disease

Background:

  • Corneal neovascularization (CoNV) disrupts the avascular cornea, impairing vision.
  • Multiple factors like infection, inflammation, hypoxia, and trauma trigger CoNV.
  • CoNV significantly reduces visual acuity and quality of life.

Purpose of the Study:

  • To review potential therapeutic targets for CoNV.
  • To explore current and emerging treatment strategies for CoNV.
  • To highlight the need for multifaceted and combination therapies.

Main Methods:

  • Literature review of CoNV pathophysiology and treatments.
  • Analysis of pro- and anti-angiogenic factors.
  • Evaluation of current therapies (corticosteroids, anti-VEGF, laser) and emerging options (immunosuppressants, drug delivery systems, gene therapy).

Main Results:

  • CoNV is driven by complex angiogenic factor interplay.
  • Current treatments include topical steroids, anti-VEGF, and laser modalities.
  • Emerging therapies show promise, including gene-based approaches (Aganirsen, CRISPR/Cas9) and advanced drug delivery.

Conclusions:

  • Targeting angiogenic mediators offers therapeutic potential for CoNV.
  • Combination therapies are likely necessary for optimal management due to CoNV's multifactorial nature.
  • Further research and clinical trials are crucial for effective CoNV treatment and remission.