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Relationships Between Hematological Variables and Bone Metabolism in Elite Female Trail Runners
Marta Carrasco-Marginet1,2,3, Silvia Puigarnau1,2, Javier Espasa-Labrador2
1National Institute of Physical Education of Catalonia (INEFC), Av. De l'Estadi 12-22, 08038 Barcelona, Spain.
Healthcare (Basel, Switzerland)
|January 28, 2026
Summary
Elite female trail runners
Area of Science:
- Sports Medicine
- Endocrinology
- Bone Metabolism
Background:
- Investigated hematological and bone metabolism in elite female trail runners.
- Focused on identifying hematological factors related to bone health.
- Examined 44 hematological variables and bone mineral density (BMD) and content (BMC).
Purpose of the Study:
- To explore the relationship between hematological variables and bone health in elite female trail runners.
- To identify specific hematological markers associated with bone mineral density and content.
- To understand the interplay of mineral homeostasis and hormonal balance in skeletal integrity.
Main Methods:
- Cross-sectional study of 35 elite female trail runners.
- Analysis of 44 hematological variables (biochemical, hormonal, iron, etc.).
- Dual-energy X-ray absorptiometry (DXA) for BMD and BMC assessment; correlation and regression analyses.
Main Results:
- Magnesium negatively correlated with BMC and BMD, especially in the lumbar spine and whole body.
- Follicle-stimulating hormone positively associated with BMD, suggesting a protective role.
- Calcium and thyroid hormones linked to regional bone properties, indicating site-specific vulnerabilities.
Conclusions:
- Complex interplay between mineral homeostasis and hormonal balance impacts skeletal integrity in female trail runners.
- Findings provide a basis for guidelines supporting athlete health and performance.
- Further longitudinal research is needed to confirm associations.
Keywords:
biochemical profilebone mineral densityendurance athleteshormonal and endocrine adaptationsiron metabolismlow energy availabilityMore Related Videos
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